Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System

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	Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System
	Liu, Qiang ; Zhang, Juan ; Zerbinatti, Celina ; Zhan, Yan ; Kolber, Benedict J. ; Herz, Joachim ; Muglia, Louis J. ; Bu, Guojun ; Bu GJ(卜国军)
刊名	http://dx.doi.org/10.1371/journal.pbio.1000575
	2011-01
关键词	BRAIN APOLIPOPROTEIN-E ALPHA-2-MACROGLOBULIN RECEPTOR MELANOCORTIN SYSTEM GENE KNOCKOUT MOUSE-BRAIN PROTEIN EXPRESSION BALANCE MICE NEURONS
英文摘要	National Institutes of Health (NIH) [R01 AG02792405, P01 AG03012801, HL20948, HL63762]; Washington University DRTC [5P60DK020579]; Alzheimer's Association; Obesity is a growing epidemic characterized by excess fat storage in adipocytes. Although lipoprotein receptors play important roles in lipid uptake, their role in controlling food intake and obesity is not known. Here we show that the lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis. Conditional deletion of the Lrp1 gene in the brain resulted in an obese phenotype characterized by increased food intake, decreased energy consumption, and decreased leptin signaling. LRP1 directly binds to leptin and the leptin receptor complex and is required for leptin receptor phosphorylation and Stat3 activation. We further showed that deletion of the Lrp1 gene specifically in the hypothalamus by Cre lentivirus injection is sufficient to trigger accelerated weight gain. Together, our results demonstrate that the lipoprotein receptor LRP1, which is critical in lipid metabolism, also regulates food intake and energy homeostasis in the adult central nervous system.
语种	英语
出版者	PLOS BIOL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93273]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Liu, Qiang,Zhang, Juan,Zerbinatti, Celina,et al. Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System[J]. http://dx.doi.org/10.1371/journal.pbio.1000575,2011.
APA	Liu, Qiang.,Zhang, Juan.,Zerbinatti, Celina.,Zhan, Yan.,Kolber, Benedict J..,...&卜国军.(2011).Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System.http://dx.doi.org/10.1371/journal.pbio.1000575.
MLA	Liu, Qiang,et al."Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System".http://dx.doi.org/10.1371/journal.pbio.1000575 (2011).