Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice

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	Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice
	Xia, Junjie ; Chen, Jibing ; Shao, Wei ; Lan, Tianshu ; Wang, Yongzhi ; Xie, Baiyi ; Thorlacius, Henrik ; Tian, Feng ; Huang, Ruxin ; Qi, Zhongquan ; Chen JB(陈继冰) ; Tian F(田风)
刊名	http://dx.doi.org/10.1111/j.1432-2277.2010.01106.x
	2010-09
关键词	IN-VIVO B-CELLS REJECTION OX40 TRANSPLANTATION DONOR GENERATION SURVIVAL NAIVE IMMUNITY
英文摘要	joint research project of health and education, Fujian Province [WKJ2008-2-50]; P>Memory T cells are known to play a key role in prevention of allograft tolerance in alloantigen-primed mice. Here, we used an adoptively transferred memory T cell model and an alloantigen-primed model to evaluate the abilities of different combinations of monoclonal antibodies (mAb) to block key signaling pathways involved in activation of effector and memory T cells. In the adoptively transferred model, the use of anti-CD134L mAb effectively prevented activation of CD4+ memory T cells and significantly prolonged islet survival, similar to the action of anti-CD122 mAb to CD8+ memory T cells. In the alloantigen-primed model, use of anti-CD134L and anti-CD122 mAbs in addition to co-stimulatory blockade with anti-CD154 and anti-LFA-1 prolonged secondary allograft survival and significantly reduced the proportion of memory T cells; meanwhile, this combination therapy increased the proportion of regulatory T cells (Tregs) in the spleen, inhibited lymphocyte infiltration in the graft, and suppressed alloresponse of recipient splenic T cells. However, we also detected high levels of alloantibodies in the serum which caused high levels of damage to the allogeneic spleen cells. Our results suggest that combination of four mAbs can significantly suppress the function of memory T cells and prolong allograft survival in alloantigen primed animals.
语种	英语
出版者	TRANSPL INT
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93185]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Xia, Junjie,Chen, Jibing,Shao, Wei,et al. Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice[J]. http://dx.doi.org/10.1111/j.1432-2277.2010.01106.x,2010.
APA	Xia, Junjie.,Chen, Jibing.,Shao, Wei.,Lan, Tianshu.,Wang, Yongzhi.,...&田风.(2010).Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice.http://dx.doi.org/10.1111/j.1432-2277.2010.01106.x.
MLA	Xia, Junjie,et al."Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice".http://dx.doi.org/10.1111/j.1432-2277.2010.01106.x (2010).