Abnormal Epithelial Differentiation and Tear Film Alteration in Pinguecula

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	Abnormal Epithelial Differentiation and Tear Film Alteration in Pinguecula
	Dong, Nuo ; Li, Wei ; Lin, Hui ; Wu, Huping ; Li, Cheng ; Chen, Wensheng ; Qin, Wenjuan ; Quyang, Luowa ; Wang, Hua ; Liu, Zuguo ; Dong N(董诺) ; Li W(李炜) ; Wu HP(吴护平) ; Li C(李程) ; Chen WS(陈文生) ; Liu ZG(刘祖国)
刊名	http://dx.doi.org/10.1167/iovs.08-2905
	2009-06
关键词	INTERMEDIATE-FILAMENT EXPRESSION BLUE MOUNTAINS EYE OCULAR SURFACE SQUAMOUS METAPLASIA CORNEAL EPITHELIUM IMPRESSION CYTOLOGY P53 EXPRESSION LIMBAL TUMORS PTERYGIUM CELLS
英文摘要	National Natural Science Foundation of China [30872809, 30600697, 30572001]; National High-tech Research and Development Program 863 of China [2006AA02A131]; Science and Technology Plan of Xiamen City [3502Z20073016]; PURPOSE. To investigate the differentiation of conjunctival epithelium and tear film function in pingueculae. METHODS. Twelve patients (12 eyes) who underwent simple excision for pingueculae were enrolled in the study. Immuno-staining for K14, K19, K10, MUC5AC, Pax6, P63, Ki67, and K16 was performed on the pinguecula epithelium and normal conjunctival epithelium. Schirmer I test results and tear film break-up time (TFBUT) were evaluated just before and 1 month after surgery. RESULTS. Abnormal epidermal differentiation of pinguecula tissue, as evidenced by a decline in or absence of Pax6 expression, was accompanied by a decline in or absence of K19 keratin and MUC5AC, and an increase in K10 and K14 keratin. Furthermore, the pinguecula epithelium was actively proliferating, as evidenced by positive expression of Ki67, P63, and K16 keratin. The Schirmer I test results did not indicate any significant differences before and after surgery. However, the TFBUT was significantly prolonged 1 month after surgery compared with before surgery. CONCLUSIONS. Pinguecula is a condition of abnormal epithelial differentiation. It is characterized by squamous proliferation and metaplasia, resulting in instability of tear film with normal basic tear secretion. (Invest Ophthalmol Vis Sci. 2009; 50: 2710-2715) DOI: 10.1167/iovs.08-2905
语种	英语
出版者	INVEST OPHTH VIS SCI
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93160]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Dong, Nuo,Li, Wei,Lin, Hui,et al. Abnormal Epithelial Differentiation and Tear Film Alteration in Pinguecula[J]. http://dx.doi.org/10.1167/iovs.08-2905,2009.
APA	Dong, Nuo.,Li, Wei.,Lin, Hui.,Wu, Huping.,Li, Cheng.,...&刘祖国.(2009).Abnormal Epithelial Differentiation and Tear Film Alteration in Pinguecula.http://dx.doi.org/10.1167/iovs.08-2905.
MLA	Dong, Nuo,et al."Abnormal Epithelial Differentiation and Tear Film Alteration in Pinguecula".http://dx.doi.org/10.1167/iovs.08-2905 (2009).