Hollow-Bone-Graft Dynamic Hip Screw Can Fix and Promote Bone Union after Femoral Neck Fracture: an Experimental Research

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	Hollow-Bone-Graft Dynamic Hip Screw Can Fix and Promote Bone Union after Femoral Neck Fracture: an Experimental Research
	Shen, Jia-zuo ; Yao, Jian-fei ; Lin, Da-sheng ; Lian, Ke-jian ; Ding, Zhen-qi ; Lin, Bin ; Guo, Zhi-min ; Zhang, Ming-hua ; Li, Qiang ; Li, Lin ; Qi, Peng ; Lin DS(林达生) ; Lian KJ(练克俭) ; Ding ZQ(丁真奇) ; Lin B(林斌) ; Guo ZM(郭志民)
刊名	http://dx.doi.org/10.7150/ijms.4567
	2012
关键词	FOLLOW-UP FIXATION HEMIARTHROPLASTY OSTEOTOMY OUTCOMES
英文摘要	Nanjing Military Region [10MA073]; Background: Delayed bone union, nonunion or osteonecrosis often occur after femoral neck fractures in young adults. Secondary bone healing requires strong internal fixation, intramedullary pressure reduction and early functional exercise. Objective: To compare bone healing of femoral neck fractures treated with hollow-bone-graft dynamic hip screws (Hb-DHS) and standard dynamic hip screws (DHS) in an animal model. Design: Testing of specifically designed fixation devices in a pig animal model. Interventions/Methods: We designed Hb-DHS and DHS devices appropriate to the femoral neck and head of experimental animals and used them in eight pigs (4-month-old, male or female, 30-40 kg/each). Under anesthesia, we induced medium neck type, Garden III type femoral neck fractures in each pig with fracture gaps of 0.5 mm and then fixed each left femur with Hb-DHS and each right femur with DHS. We assessed the animals radiographically and by postmortem visual appraisal of evidence of bone healing 8 and 16 weeks postoperatively. Results: There were significant differences in radiographic and general findings between the Hb-DHS and DHS groups at weeks 8 and 16 postoperatively. We found statistically significant differences between the Hb-DHS and DHS groups in bone healing scores, trabecular bone volume percentage and bone mineral density as assessed on plain radiographs and computed tomography images (P < 0.05). There were also significant differences between the Hb-DHS and DHS groups in postmortem visually assessed indicators of bone healing at both 8 and 16 weeks postoperatively. Conclusions: The Hb-DHS device promotes femoral neck bone union, stimulates trabecular bone formation, increases BMD and has advantages over DHS for internal fixation of femoral neck fractures. This animal experiment will contribute to developing optimal treatment for femoral neck fractures in young adults.
语种	英语
出版者	INT J MED SCI
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93134]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Shen, Jia-zuo,Yao, Jian-fei,Lin, Da-sheng,et al. Hollow-Bone-Graft Dynamic Hip Screw Can Fix and Promote Bone Union after Femoral Neck Fracture: an Experimental Research[J]. http://dx.doi.org/10.7150/ijms.4567,2012.
APA	Shen, Jia-zuo.,Yao, Jian-fei.,Lin, Da-sheng.,Lian, Ke-jian.,Ding, Zhen-qi.,...&郭志民.(2012).Hollow-Bone-Graft Dynamic Hip Screw Can Fix and Promote Bone Union after Femoral Neck Fracture: an Experimental Research.http://dx.doi.org/10.7150/ijms.4567.
MLA	Shen, Jia-zuo,et al."Hollow-Bone-Graft Dynamic Hip Screw Can Fix and Promote Bone Union after Femoral Neck Fracture: an Experimental Research".http://dx.doi.org/10.7150/ijms.4567 (2012).