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	Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci
	Qiyuan Li ; Li QY(李奇渊) ; Ji-Heui Seo ; Barbara Stranger ; Aaron McKenna ; Itsik Pe’er ; Thomas LaFramboise ; Myles Brown ; Svitlana Tyekucheva ; Matthew L. Freedman
	2013-01-31
关键词	expression quantitative trait locus-based analyses Breast Cancer
英文摘要	该论文是在本文通讯作者美国哈佛大学医学院代纳法伯癌症中心马修.弗里德曼教授实验室完成的。; Germline determinants of gene expression in tumors are infrequently studied due to the complexity of transcript regulation caused by somatically acquired alterations. We performed expression quantitative trait locus (eQTL)-based analyses using the multi-level information provided in The Cancer Genome Atlas (TCGA). Of the factors we measured, cis-acting eQTLs accounted for 1.2% of the total variation of tumor gene expression, while somatic copy-number alteration and CpG methylation accounted for 7.3% and 3.3%, respectively. eQTL analyses of 15 previously reported breast cancer risk loci resulted in the discovery of three variants that are significantly associated with transcript levels (false discovery rate [FDR] < 0.1). Our trans-based analysis identified an additional three risk loci to act through ESR1, MYC, and KLF4. These findings provide a more comprehensive picture of gene expression determinants in breast cancer as well as insights into the underlying biology of breast cancer risk loci.
语种	英语
出版者	Cell Press
内容类型	期刊论文
源URL	[http://news.xmu.edu.cn/s/13/t/542/02/84/info131716.htm]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Qiyuan Li,Li QY,Ji-Heui Seo,et al. Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci[J],2013.
APA	Qiyuan Li.,李奇渊.,Ji-Heui Seo.,Barbara Stranger.,Aaron McKenna.,...&Matthew L. Freedman.(2013).Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci..
MLA	Qiyuan Li,et al."Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci".(2013).

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