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	The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer
	Gao, Jingchun ; Yang, Xiangjun ; Yang XJ(杨湘军) ; Yin, Ping ; Hu, Wenfeng ; Liao, Hongfeng ; Miao, Zhihui ; Pan, Chao ; Li, Na
	2012-04
关键词	minibrain-related kinase/dual specificity tyrosine-phosphorylation-regulated kinase 1B forkhead subclass O apoptosis ovarian cancer
英文摘要	Minibrain-related kinase (Mirk) is a serine/threonine kinase which is also known as the dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B). It is known that Dyrk1A, the closest family member to Mirk/Dyrk1B can mediate cellular localization of mammalian forkhead subclass O (FoxO1), a transcription factor, although the effect of Mirk/Dyrk1B on Foxes factors remains to be defined. In this study, we showed that Mirk/Dyrk1B protein was overexpressed in 5 of 8 ovarian cancer cell lines and negatively correlated with the protein level of FoxO factors (FoxO1+FoxO3A). Knockdown of Mirk by small interfering RNA (siRNA) resulted in cell apoptosis and sensitized cells to cisplatin accompanied by nuclear translocation of FoxO1 and/or FoxO3A as well as increased Bim, TRADD, cleaved caspase-3 and PARP. Furthermore, combined siRNAs of Mirk with FoxO1 and/or FoxO3A led to fewer apoptotic cells and cisplatin sensitivity compared to Mirk siRNA alone, suggesting that FoxO is involved in Mirk-mediated cell survival and chemosensitivity of ovarian cancer. Taken together, Mirk/Dyrk1B plays an important role in ovarian cancer cell survival through modulating FoxO translocation and may be a novel therapeutic target for ovarian cancer.; National Natural Science Foundation of China [81172457]; Natural Science Foundation of Fujian Province, P.R. China [2010J01236]
语种	英语
出版者	SPANDIDOS PUBL LTD
内容类型	期刊论文
源URL	[http://dx.doi.org/10.3892/ijo.2011.1293]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Gao, Jingchun,Yang, Xiangjun,Yang XJ,et al. The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer[J],2012.
APA	Gao, Jingchun.,Yang, Xiangjun.,杨湘军.,Yin, Ping.,Hu, Wenfeng.,...&Li, Na.(2012).The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer..
MLA	Gao, Jingchun,et al."The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer".(2012).

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