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	瓦氏效应——哺乳动物生殖过程中的有氧糖酵解; Warburg Effect: Aerobic Glycolysis During Mammalian Reproduction
	左茹娟 ; 杨增明
	2015-02-09
关键词	瓦氏效应 糖酵解 生殖 Warburg effect glycolysis reproduction
英文摘要	糖代谢是生物体赖以生存的基本生化过程之一.哺乳动物体内不同细胞对葡萄糖的利用方式不同.摄氧充足时,细胞通过氧化磷酸化在线粒体中进行有氧呼吸;缺氧的细胞则选择抑制氧化磷酸化,通过糖酵解产生乳酸.但有些细胞在有氧条件下也能进行糖酵解,从而产生大量的乳酸,这种糖酵解途径称为瓦氏效应.以前认为瓦氏效应主要存在于肿瘤细胞中,但近来发现在哺乳动物的生殖过程中也存在瓦氏效应.本文综述了哺乳动物生殖发育过程的瓦氏效应及其与一些生殖疾病的关系.; Glucose metabolism is one of essential biochemical processes for the survival of living species.In mammals, glucose is utilized in different ways among the different types of cells under different situations.The cells under plenty of oxygen can use oxidative phosphorylation during aerobic respiration.Under hypoxic condition, cells repress oxidative phosphorylation and ferment glucose to lactate.However, some cells choose"Warburg effect", an activated glycolytic flux even under normoxia, as a way to metabolise glucose.It is known that Warburg effect is favored by tumor cells.Recently, accumulating evidences show that Warburg effect is also involved in mammalian reproduction.Here we summarize the advances on Warburg effect in mammalian reproduction and fertility-related diseases.; 国家自然科学基金资助项目(31272263)~~
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/119344]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	左茹娟,杨增明. 瓦氏效应——哺乳动物生殖过程中的有氧糖酵解, Warburg Effect: Aerobic Glycolysis During Mammalian Reproduction[J],2015.
APA	左茹娟,&杨增明.(2015).瓦氏效应——哺乳动物生殖过程中的有氧糖酵解..
MLA	左茹娟,et al."瓦氏效应——哺乳动物生殖过程中的有氧糖酵解".(2015).

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