Tributyltin exposure results in craniofacial cartilage defects in rockfish (Sebastiscus marmoratus) embryos

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	Tributyltin exposure results in craniofacial cartilage defects in rockfish (Sebastiscus marmoratus) embryos
	Zhang, Jiliang ; Zuo, Zhenghong ; Sun, Ping ; Wang, Hongwei ; Yu, Ang ; Wang, Chonggang ; Zuo ZH(左正宏)
刊名	http://dx.doi.org/10.1016/j.marenvres.2011.12.008
	2012-06
关键词	VITAMIN-D-RECEPTOR PARALICHTHYS-OLIVACEUS EMBRYOS BASS DICENTRARCHUS-LABRAX RETINOIC ACID JAPANESE FLOUNDER SONIC-HEDGEHOG ZEBRAFISH DEVELOPMENT SELECTIVE AGONIST HOXD-4 EXPRESSION ORYZIAS-LATIPES
英文摘要	National Natural Science Foundation of China [20977071, 20777061]; Tributyltin (TBT) is a ubiquitous marine environmental contaminant, which has been known to cause axial skeletal deformities in fish embryos. However, the effects of TBT on the craniofacial cartilage development of fishes remain unclear. The present study was designed to investigate the effects of waterborne TBT at environmental levels (0, 0.1, 1, and 10 ng L-1 as Sn) on craniofacial cartilage development in embryos of the rockfish (Sebastiscus marmoratus). Our study showed that TBT exposure induced craniofacial skeletal deformities, such as reduction of the craniofacial skeleton elements and a shorter lower jaw. The expressions of retinoic acid receptor alpha, sonic hedgehog, and proliferating cell nuclear antigen were depressed and the expressions of vitamin D receptor were increased in the rockfish embryos after TBT exposure. In addition, the activities of Ca2+-ATPase were inhibited after TBT exposure. These results suggested that TBT might perturb the proliferation and differentiation of chondrocytes, and disturb calcium homeostasis, thus disorganizing craniofacial skeletal development. (C) 2012 Elsevier Ltd. All rights reserved.
语种	英语
出版者	Elsevier Ltd
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90909]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhang, Jiliang,Zuo, Zhenghong,Sun, Ping,et al. Tributyltin exposure results in craniofacial cartilage defects in rockfish (Sebastiscus marmoratus) embryos[J]. http://dx.doi.org/10.1016/j.marenvres.2011.12.008,2012.
APA	Zhang, Jiliang.,Zuo, Zhenghong.,Sun, Ping.,Wang, Hongwei.,Yu, Ang.,...&左正宏.(2012).Tributyltin exposure results in craniofacial cartilage defects in rockfish (Sebastiscus marmoratus) embryos.http://dx.doi.org/10.1016/j.marenvres.2011.12.008.
MLA	Zhang, Jiliang,et al."Tributyltin exposure results in craniofacial cartilage defects in rockfish (Sebastiscus marmoratus) embryos".http://dx.doi.org/10.1016/j.marenvres.2011.12.008 (2012).