PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy

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	PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy
	Cheng, Liang ; Gong, Hua ; Zhu, Wenwen ; Liu, Jingjing ; Wang, Xiaoyong ; Liu, Gang ; Liu, Zhuang ; Liu JJ(刘晶晶) ; Liu G(刘刚)
刊名	http://dx.doi.org/10.1016/j.biomaterials.2014.09.004
	2014
关键词	Diagnosis Infrared devices Magnetic resonance imaging Mammals Medical imaging Photoacoustic effect Tomography Tumors
英文摘要	Theranostic agents with both imaging and therapeutic functions have attracted enormous interests in cancer diagnosis and treatment in recent years. In this work, we develop a novel theranostic agent based on Prussian blue nanocubes (PB NCs), a clinically approved agent with strong near-infrared (NIR) absorbance and intrinsic paramagnetic property, for invivo bimodal imaging-guided photothermal therapy. After being coated with polyethylene glycol (PEG), the obtained PB-PEG NCs are highly stable in various physiological solutions. Invivo T1-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) bimodal imaging uncover that PB-PEG NCs after intravenous (i.v.) injection show high uptake in the tumor. Utilizing the strong and super stable NIR absorbance of PB, invivo cancer treatment is then conducted upon i.v. injection of PB-PEG NCs followed by NIR laser irradiation of the tumors, achieving excellent therapeutic efficacy in a mouse tumor model. Comprehensive blood tests and careful histological examinations reveal no apparent toxicity of PB-PEG NCs to mice at our tested dose, which is two-fold of the imaging/therapy dose, within two months. Our work highlights the great promise of Prussian blue with well engineered surface coating as a multifunctional nanoprobe for imaging-guided cancer therapy. ? 2014 Elsevier Ltd.
语种	英语
出版者	Elsevier Ltd
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90885]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Cheng, Liang,Gong, Hua,Zhu, Wenwen,et al. PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy[J]. http://dx.doi.org/10.1016/j.biomaterials.2014.09.004,2014.
APA	Cheng, Liang.,Gong, Hua.,Zhu, Wenwen.,Liu, Jingjing.,Wang, Xiaoyong.,...&刘刚.(2014).PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy.http://dx.doi.org/10.1016/j.biomaterials.2014.09.004.
MLA	Cheng, Liang,et al."PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy".http://dx.doi.org/10.1016/j.biomaterials.2014.09.004 (2014).