Protective immunity against HEV

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	Protective immunity against HEV
	Huang, Shou-Jie ; Liu, Xiao-Hui ; Zhang, Jun ; Ng, Mun-Hon ; Zhang J(张军)
刊名	http://dx.doi.org/10.1016/j.coviro.2013.10.003
	2014
关键词	HEPATITIS-E-VIRUS INDUCED LIVER-INJURY DEVELOPED-COUNTRIES BLOOD-DONORS TRANSPLANT RECIPIENTS E INFECTION ZOONOSIS PREVALENCE ANTIBODIES OUTBREAK
英文摘要	National Natural Science Foundation of China [81373061]; National Diagnostics and Vaccine Development in Infectious Diseases: Policy Guidance Project [2011FU125Z04]; National Major Scientific and Technological Special Project for "Significant New Drugs Development" [2013ZX09101017]; Rural community of Dongtai City in eastern China is endemic for hepatitis E virus (HEV), with the zoonotic genotype 4 virus predominating. The virus appears to be widely distributed in environment at generally low levels, such that infection is common, but >97% of which are asymptomatic and provoke a modest antibody response. Naturally acquired immunity affords 75% protection against infection, prevents disease caused by primary infection and alleviates severity of the disease caused by the residual infection that had evaded host immune surveillance. The protection, however, is extended to a minority, while leaving the majority of population essentially without the benefits of immune protection. Vaccination affords similar level of protection as does natural immunity, but expands the protective coverage to the entire population.
语种	英语
出版者	ELSEVIER SCI LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90800]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Huang, Shou-Jie,Liu, Xiao-Hui,Zhang, Jun,et al. Protective immunity against HEV[J]. http://dx.doi.org/10.1016/j.coviro.2013.10.003,2014.
APA	Huang, Shou-Jie,Liu, Xiao-Hui,Zhang, Jun,Ng, Mun-Hon,&张军.(2014).Protective immunity against HEV.http://dx.doi.org/10.1016/j.coviro.2013.10.003.
MLA	Huang, Shou-Jie,et al."Protective immunity against HEV".http://dx.doi.org/10.1016/j.coviro.2013.10.003 (2014).