Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice

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	Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice
	Xia, Xiao-chun ; Chen, Qiang ; Liu, Kun ; Mo, Ping-li ; Zhu, Jing-wei ; Zhuang, Ming-qiang ; Shen, Yue-mao ; Yu, Chun-dong ; Chen Q(陈强) ; Mo PL(莫萍丽) ; Shen YM(沈月毛) ; Yu CD(俞春东)
刊名	http://dx.doi.org/10.1016/j.intimp.2013.06.029
	2013
关键词	FC-EPSILON-RI ALLERGIC RESPONSE DEGRANULATION RECEPTOR SYK INFLAMMATION PROTEIN
英文摘要	Program for New Century Excellent Talents in University of the Ministry of Education [NCET-10-0718]; Fundamental Research Funds for the Central Universities [2012121038]; Natural Science Foundation of China [31170819]; Mycoepoxydiene (MED) is a polyketide isolated from a marine fungus associated with mangrove forest. It has been shown that MED has many kinds of effects such as anti-cancer and anti-inflammatory activities. However, its effects on anaphylaxis are still unknown. Mast cells play a pivotal role in IgE-mediated allergic response. Aggregation of the high affinity IgE receptor (Fc epsilon RI) on the surface of mast cell activates a cascade of signaling events leading to the degranulation and cytokine production in mast cells. Our study showed that MED could significantly suppress antigen-stimulated degranulation and cytokine production in mast cells and IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. Furthermore, we found that MED suppressed antigen-induced activation of Syk, and subsequently inhibited the phosphorylation of PLC gamma 1, Akt, and MAPKs such as extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 in mast cells. Collectively, our study demonstrates that MED can inhibit the activation of mast cells and protect mice from mast cell-mediated allergic response through inhibiting the activation of Syk. These results suggest that MED is a potential compound for developing a promising anti-anaphylaxis drug. (C) 2013 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90685]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Xia, Xiao-chun,Chen, Qiang,Liu, Kun,et al. Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice[J]. http://dx.doi.org/10.1016/j.intimp.2013.06.029,2013.
APA	Xia, Xiao-chun.,Chen, Qiang.,Liu, Kun.,Mo, Ping-li.,Zhu, Jing-wei.,...&俞春东.(2013).Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice.http://dx.doi.org/10.1016/j.intimp.2013.06.029.
MLA	Xia, Xiao-chun,et al."Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice".http://dx.doi.org/10.1016/j.intimp.2013.06.029 (2013).