Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-alpha and Ameliorates Hepatosteatosis in Diabetic db/db Mice

CORC > 厦门大学 > 生命科学－已发表论文

	Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-alpha and Ameliorates Hepatosteatosis in Diabetic db/db Mice
	Qiu, Longxin ; Lin, Jianhui ; Xu, Fangui ; Gao, Yuehong ; Zhang, Cuilin ; Liu, Ying ; Luo, Yu ; Yang, James Y. ; Qiu LX(邱龙新) ; Zhang CL(张翠林) ; Yang CY(杨朝勇)
刊名	http://dx.doi.org/10.1155/2012/789730
	2012
关键词	FATTY LIVER-DISEASE INSULIN-RESISTANCE PPAR-ALPHA METABOLIC SYNDROME GENE-EXPRESSION POLYOL PATHWAY FRUCTOSE STEATOSIS ENZYME RATS
英文摘要	Natural Science Foundation of Fujian Province, China [2009J01180]; Science Planning Program of Fujian Province [2010J1008]; National Science Foundation of China [30970649]; We previously demonstrated in streptozotocin-induced diabeticmice that deficiency or inhibition of aldose reductase (AR) caused significant dephosphorylation of hepatic transcriptional factor PPAR alpha, leading to its activation and significant reductions in serum lipid levels. Herein, we report that inhibition of AR by zopolrestat or by a short-hairpin RNA (shRNA) against AR caused a significant reduction in serum and hepatic triglycerides levels in 10-week old diabetic db/db mice. Meanwhile, hyperglycemia-induced phosphorylation of hepatic ERK1/2 and PPAR alpha was significantly attenuated in db/db mice treated with zopolrestat or AR shRNA. Further, in comparison with the untreated db/db mice, the hepatic mRNA expression of Aco and ApoA5, two target genes for PPAR alpha, was increased by 93% (P < 0.05) and 73% (P < 0.05) in zopolrestat-treated mice, respectively. Together, these data indicate that inhibition of AR might lead to significant amelioration in hyperglycemia-induced dyslipidemia and nonalcoholic fatty liver disease.
语种	英语
出版者	EXP DIABETES RES
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/90574]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Qiu, Longxin,Lin, Jianhui,Xu, Fangui,et al. Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-alpha and Ameliorates Hepatosteatosis in Diabetic db/db Mice[J]. http://dx.doi.org/10.1155/2012/789730,2012.
APA	Qiu, Longxin.,Lin, Jianhui.,Xu, Fangui.,Gao, Yuehong.,Zhang, Cuilin.,...&杨朝勇.(2012).Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-alpha and Ameliorates Hepatosteatosis in Diabetic db/db Mice.http://dx.doi.org/10.1155/2012/789730.
MLA	Qiu, Longxin,et al."Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-alpha and Ameliorates Hepatosteatosis in Diabetic db/db Mice".http://dx.doi.org/10.1155/2012/789730 (2012).