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	Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels
	Bossy-Wetzel, E. ; Talantova, M. V. ; Lee, W. D. ; Scholzke, M. N. ; Harrop, A. ; Mathews, E. ; Gotz, T. ; Han, J. H. ; Ellisman, M. H. ; Perkins, G. A. ; Lipton, S. A. ; Han JH(韩家淮)
	2004
关键词	METHYL-D-ASPARTATE P38 MAP KINASE S-NITROSYLATION SUPEROXIDE-PRODUCTION HIPPOCAMPAL-NEURONS CEREBRAL-ISCHEMIA VOLUME REGULATION CASPASE CLEAVAGE CYTOCHROME-C APOPTOSIS
英文摘要	Nitric oxide (NO) and zinc (Zn2+) are implicated in the pathogenesis of cerebral ischemia and neurodegenerative diseases. However, their relationship and the molecular mechanism of their neurotoxic effects remain unclear. Here we show that addition of exogenous NO or NMDA (to increase endogenous NO) leads to peroxynitrite (ONOO-) formation and consequent Zn2+ release from intracellular stores in cerebrocortical neurons. Free Zn2+ in turn induces respiratory block, mitochondrial permeability transition (mPT), cytochrome c release, generation of reactive oxygen species (ROS), and p38 MAP kinase activation. This pathway leads to caspase-independent K+ efflux with cell volume loss and apoptotic-like death. Moreover, Zn2+ chelators, ROS scavengers, Bcl-x(L), dominant-interfering p38, or K+ channel blockers all attenuate NO-induced K+ efflux, cell volume loss, and neuronal apoptosis. Thus, these data establish a new form of crosstalk between NO and Zn2+ apoptotic signal transduction pathways that may contribute to neurodegeneration.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65890]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Bossy-Wetzel, E.,Talantova, M. V.,Lee, W. D.,et al. Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels[J],2004.
APA	Bossy-Wetzel, E..,Talantova, M. V..,Lee, W. D..,Scholzke, M. N..,Harrop, A..,...&韩家淮.(2004).Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels..
MLA	Bossy-Wetzel, E.,et al."Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels".(2004).

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