Determinants of public T cell responses

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	Determinants of public T cell responses
	Li, Hanjie ; Ye, Congting ; Ji, Guoli ; Han, Jiahuai ; Han JH(韩家淮)
刊名	http://dx.doi.org/10.1038/cr.2012.1
	2012-01
关键词	TCR ALPHA-CHAIN V-H GENES V(D)J RECOMBINATION MELANOMA PATIENTS BETA USAGE CONVERGENT RECOMBINATION SOMATIC RECOMBINATION REPERTOIRE DIVERSITY POSITIVE SELECTION ADAPTIVE MUTATION
英文摘要	National Basic Research Program of China (973 Program) [2009CB522200]; National Natural Science Foundation of China [30830092, 30921005, 91029304, 81061160512, 61174161]; Sino-Swiss International Collaboration Grant [2009DFA32760]; Science Planning Program of Fujian Province [2009J1010]; Specialized Research Fund for the Doctoral Program of Higher Education of China [20090121110022]; Xiamen University [2011121047, 201112G018, CXB2011035]; Historically, sharing T cell receptors (TCRs) between individuals has been speculated to be impossible, considering the dramatic discrepancy between the potential enormity of the TCR repertoire and the limited number of T cells generated in each individual. However, public T cell response, in which multiple individuals share identical TCRs in responding to a same antigenic epitope, has been extensively observed in a variety of immune responses across many species. Public T cell responses enable individuals within a population to generate similar antigen-specific TCRs against certain ubiquitous pathogens, leading to favorable biological outcomes. However, the relatively concentrated feature of TCR repertoire may limit T cell response in a population to some other pathogens. It could be a great benefit for human health if public T cell responses can be manipulated. Therefore, the mechanistic insight of public TCR generation is important to know. Recently, high-throughput DNA sequencing has revolutionized the study of immune receptor repertoires, which allows a much better understanding of the factors that determine the overlap of TCR repertoire among individuals. Here, we summarize the current knowledge on public T-cell response and discuss future challenges in this field.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65745]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Li, Hanjie,Ye, Congting,Ji, Guoli,et al. Determinants of public T cell responses[J]. http://dx.doi.org/10.1038/cr.2012.1,2012.
APA	Li, Hanjie,Ye, Congting,Ji, Guoli,Han, Jiahuai,&韩家淮.(2012).Determinants of public T cell responses.http://dx.doi.org/10.1038/cr.2012.1.
MLA	Li, Hanjie,et al."Determinants of public T cell responses".http://dx.doi.org/10.1038/cr.2012.1 (2012).