QQ客服 官方微博 反馈留言

	Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein
	Tao T(陶涛)
	1996
关键词	CL CHANNEL CFTR GENE INACTIVATION CELLS
英文摘要	The cystic fibrosis transmembrane conductance regulator (CFTR) constitutes a linear conductance chloride channel, which is regulated by cAMP-dependent protein kinase phosphorylation at multiple sites located in the intracellular regulatory (R) domain, Studies in a lipid bilayer system, reported here, provide evidence for the control of CFTR chloride channel by its R domain, The exogenous R domain protein (encoded by exon 13 plus 85 base pairs of exon 14) interacted specifically with the CFTR molecule and inhibited the chloride conductance in a phosphorylation-dependent manner. Only the unphosphorylated R domain protein blocked the CFTR channel, Such functional interaction suggests that the putative gating particle of the CFTR chloride channel resides in the R domain.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65697]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Tao T. Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein[J],1996.
APA	陶涛.(1996).Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein..
MLA	陶涛."Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein".(1996).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。