Baifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels

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	Baifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels
	Chi, S. ; Cai, W. ; Liu, P. ; Zhang, Z. ; Chen, X. ; Gao, L. ; Qi, J. ; Bi, L. ; Chen, L. ; Qi, Z. ; Chen L(陈亮)
刊名	http://dx.doi.org/10.1038/cddis.2009.10
	2010-01
关键词	CA2+-ACTIVATED K+ CHANNELS CEREBRAL-ARTERY OCCLUSION POTASSIUM CHANNELS HIPPOCAMPAL SLICES NEURONAL SURVIVAL LARGE-CONDUCTANCE NMDA RECEPTOR FATTY-ACIDS IN-VITRO STROKE
英文摘要	NSFC [30470447, 30872725]; 973 program [2005CB522804, 2006CB911003, 2009CB941701]; PCSIRT [IRT0631]; Stroke is a long-term disability and one of the leading causes of death. However, no successful therapeutic intervention is available for the majority of stroke patients. In this study, we explored a traditional Chinese medicine Baifuzi (Typhonium giganteum Engl.). We show, at first, that the ethanol extract of Baifuzi exerts neuroprotective effects against brain damage induced by transient global or focal cerebral ischemia in rats and mice. Second, the extract activated large-conductance Ca2+-activated K+ channel (BKCa) channels, and BKCa channel blockade suppressed the neuroprotection of the extract, suggesting that the BKCa is the molecular target of Baifuzi. Third, Baifuzi cerebroside (Baifuzi-CB), purified from its ethanol extract, activated BKCa channels in a manner similar to that of the extract. Fourth, the stress axis hormone-regulated exon (STREX) domain of the BKCa channel directly interacted with Baifuzi-CB, and its deletion suppressed channel activation by Baifuzi-CB. These results indicate that Baifuzi-CB activated the BKCa channel through its direct interaction with the STREX domain of the channel and suggests that Baifuzi-CB merits exploration as a potential therapeutic agent for treating brain ischemia. Cell Death and Disease (2010) 1, e13; doi:10.1038/cddis.2009.10; published online 21 January 2010
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65520]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Chi, S.,Cai, W.,Liu, P.,et al. Baifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels[J]. http://dx.doi.org/10.1038/cddis.2009.10,2010.
APA	Chi, S..,Cai, W..,Liu, P..,Zhang, Z..,Chen, X..,...&陈亮.(2010).Baifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels.http://dx.doi.org/10.1038/cddis.2009.10.
MLA	Chi, S.,et al."Baifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels".http://dx.doi.org/10.1038/cddis.2009.10 (2010).