Clinical characteristics and risk factors of sporadic Hepatitis E in central China

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	Clinical characteristics and risk factors of sporadic Hepatitis E in central China
	Zhang, Shujun ; Wang, Jingjing ; Yuan, Quan ; Ge, Shengxiang ; Zhang, Jun ; Xia, Ningshao ; Tian, Deying ; Ge SX(葛胜祥)
刊名	http://dx.doi.org/10.1186/1743-422X-8-152
	2011-04-01
关键词	E VIRUS-INFECTION WILD BOAR SEROPREVALENCE LIVER HEV POPULATION CIRRHOSIS EPIDEMIC OUTBREAK WATER
英文摘要	Background: Epidemiological investigations, detections and vaccines of hepatitis E (HE) have been paid a focus of attention in prior studies, while studies on clinical features and risk factors with a large number of sporadic HE patients are scarce. Results: Sporadic HE can occur throughout the year, with the highest incidence rate in the first quarter of a year, in central of China. Of the 210 patients, 85.2% were male, and the most common clinical symptoms were jaundice (85.7%), fatigue (70.5%) and anorexia (64.8%). Total bilirubin (TBil), blood urea nitrogen (BUN), and international normalized ratio (INR) were found as major risk factors for death of HE patients. There was an overall mortality of 10%, and the mortality in the cirrhotic and non-cirrhotic group was 25% and 6.47%, respectively. Moreover, hepatitis E virus (HEV) infected patients with liver cirrhosis had a higher mortality and incidence of complications. Conclusions: TBil, BUN, and INR are major risk factors of mortality for HE. Liver cirrhosis can aggravate HE, and lead to a higher mortality. HEV infection can cause decompensation in patients with cirrhosis, as evidenced by a worsening Child-Pugh score.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65475]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhang, Shujun,Wang, Jingjing,Yuan, Quan,et al. Clinical characteristics and risk factors of sporadic Hepatitis E in central China[J]. http://dx.doi.org/10.1186/1743-422X-8-152,2011.
APA	Zhang, Shujun.,Wang, Jingjing.,Yuan, Quan.,Ge, Shengxiang.,Zhang, Jun.,...&葛胜祥.(2011).Clinical characteristics and risk factors of sporadic Hepatitis E in central China.http://dx.doi.org/10.1186/1743-422X-8-152.
MLA	Zhang, Shujun,et al."Clinical characteristics and risk factors of sporadic Hepatitis E in central China".http://dx.doi.org/10.1186/1743-422X-8-152 (2011).