Pyrene exposure influences the thyroid development of Sebastiscus marmoratus embryos

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	Pyrene exposure influences the thyroid development of Sebastiscus marmoratus embryos
	He, Chengyong ; Zuo, Zhenghong ; Shi, Xiao ; Sun, Lingbin ; Wang, Chonggang ; Wang ZG(王重刚)
刊名	http://dx.doi.org/10.1016/j.aquatox.2012.07.007
	2012-11-15
关键词	POLYCYCLIC AROMATIC-HYDROCARBONS GENE-EXPRESSION HORMONE DEIODINATION MOLECULAR-MECHANISMS IN-VITRO ZEBRAFISH TISSUE FISH SEA GROWTH
英文摘要	National Natural Science Foundation of China [20977071]; Ocean Public Welfare Scientific Research Special Appropriation Project [201005016]; Fundamental Research Funds for the Central Universities [2012121045]; Thyroid hormones play crucial roles in regulating development, morphogenesis, growth, and behavior in fishes. Some environmental pollutants have adverse effects on either development or function of the thyroid gland in fish. However, there are few reports on the effects of polycyclic aromatic hydrocarbons (PAHs) on fish thyroid. In the present study, rockfish (Sebastiscus marmoratus) embryos were exposed to pyrene (Py) for 5 days at the concentrations of 0.5, 5, and 50 nmol/L. The results showed that Py exposure decreased the expression of thyroid primordium markers, Pax2.1 and Nk2.1a as detected by quantitative PCR and in situ hybridization, and reduced the concentration of T-3, but not T-4. Thyroid receptor genes (TR alpha and TR beta) expression was down-regulated by Py. At the same time, Py exposure impaired the expression of thyroid development related genes. Fgfr2 and Hoxa3a expression, and altered the mRNA levels of thyroid function related genes, Deio1, Ttr, and Tg. In conclusion, the results demonstrated Py exposure inhibited thyroid development and influenced the function of thyroid system in rockfish embryos. (c) 2012 Elsevier B.V. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65403]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	He, Chengyong,Zuo, Zhenghong,Shi, Xiao,et al. Pyrene exposure influences the thyroid development of Sebastiscus marmoratus embryos[J]. http://dx.doi.org/10.1016/j.aquatox.2012.07.007,2012.
APA	He, Chengyong,Zuo, Zhenghong,Shi, Xiao,Sun, Lingbin,Wang, Chonggang,&王重刚.(2012).Pyrene exposure influences the thyroid development of Sebastiscus marmoratus embryos.http://dx.doi.org/10.1016/j.aquatox.2012.07.007.
MLA	He, Chengyong,et al."Pyrene exposure influences the thyroid development of Sebastiscus marmoratus embryos".http://dx.doi.org/10.1016/j.aquatox.2012.07.007 (2012).