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	The Requirement of c-Jun N-terminal Kinase 2 in Regulation of Hypoxia-inducing Factor-1alpha mRNA Stability
	Zhang, Dongyun ; Li, Jingxia ; Zhang, Min ; Gao, Guangxun ; Zuo, Zhenghong ; Yu, Yonghui ; Zhu, Linda ; Gao, Jimin ; Huang, Chuanshu ; Zuo ZH(左正宏)
	2012
关键词	NATURAL ANTISENSE TRANSCRIPTS NICKEL-INDUCED TRANSFORMATION ACTIVATED PROTEIN-KINASES T-CELL-ACTIVATION PHOSPHATIDYLINOSITOL 3-KINASE BINDING-PROTEIN NUCLEOLIN JNK HIF-1-ALPHA EXPRESSION
英文摘要	The mRNAof hif-1 alpha is considered as being constitutively and ubiquitously expressed, regardless of the level of oxygen tension. However many recent reports have showed that hif-1 alpha mRNA could be regulated by natural antisense transcripts, potential microRNAs, and low O-2. In this study, it was found that a deficiency of JNK2 expression reduced HIF-1 alpha protein induction in response to nickel treatment resulting from the impaired expression of hif-1 alpha mRNA. Both the promoter luciferase assay and mRNA degradation assay clearly showed that depletion of JNK2 affected stability of hif-1 alpha mRNA, rather than regulated its transcription. In addition, nucleolin, a classic histone chaperone, was demonstrated to physically bind to hif-1 alpha mRNA and maintain its stability. Further investigation indicated that JNK2 regulated nucleolin expression and might in turn stabilize hif-1 alpha mRNA. Collectively, we provided one more piece of evidence for the oncogenic role of JNK2 and nucleolin in regulating the cancer microenvironments by controlling HIF-1 alpha expression.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65080]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhang, Dongyun,Li, Jingxia,Zhang, Min,et al. The Requirement of c-Jun N-terminal Kinase 2 in Regulation of Hypoxia-inducing Factor-1alpha mRNA Stability[J],2012.
APA	Zhang, Dongyun.,Li, Jingxia.,Zhang, Min.,Gao, Guangxun.,Zuo, Zhenghong.,...&左正宏.(2012).The Requirement of c-Jun N-terminal Kinase 2 in Regulation of Hypoxia-inducing Factor-1alpha mRNA Stability..
MLA	Zhang, Dongyun,et al."The Requirement of c-Jun N-terminal Kinase 2 in Regulation of Hypoxia-inducing Factor-1alpha mRNA Stability".(2012).

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