Profile of Acute Infectious Markers in Sporadic Hepatitis E

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	Profile of Acute Infectious Markers in Sporadic Hepatitis E
	Huang, S. J. ; Zhang, X. F. ; Jiang, H. M. ; Yan, Q. A. ; Ai, X. ; Wang, Y. J. ; Cai, J. P. ; Jiang, L. ; Wu, T. ; Wang, Z. Z. ; Guan, L. ; Shih, J. W. K. ; Ng, M. H. ; Zhu, F. C. ; Zhang, J. ; Xia, N. S. ; Xia NS(夏宁邵)
刊名	http://dx.doi.org/10.1371/journal.pone.0013560
	2010-10-21
关键词	E VIRUS-INFECTION IMMUNOGLOBULIN-M UNITED-STATES OUTBREAK ASSAYS DISEASE ANTIBODIES DIAGNOSIS ZOONOSIS NAMIBIA
英文摘要	National Advanced Technology Research and Development Program [2006AA02A209]; National Science and Technique Major Project [2008ZX10404, 2009ZX10004-704]; National Science Fund for Distinguished Young Scholars [30925030]; Fujian Provincial Science Fund fo; Laboratory diagnosis of acute infection of hepatitis E virus (HEV) is commonly based on the detection of HEV RNA, IgM and/or rising IgG levels. However, the profile of these markers when the patients present have not been well determined. To clarify the extent of misdiagnosed sporadic hepatitis E in the initial laboratory detection, serial sera of 271 sporadic acute hepatitis cases were collected, detected and the dynamics of each acute marker during the illness course were analyzed. 91 confirmed cases of hepatitis E were identified based on the presentation of HEV RNA, IgM or at least 4 fold rising of IgG levels. 21 (23.1%) hepatitis E cases were false negative for the viral RNA and 40 (44.0%) for rising IgG, because occurrence of these markers were confined to acute phase of infection and viremia had already subsided and antibody level peaked when these patients presented. IgM was detected in 82 (90.1%) cases. It is the most prevalent of the three markers, because the antibody persisted until early convalescence. Nine cases negative for IgM were positive for rising IgG and one was also positive for the viral RNA; all of these nine cases showed high avid IgG in their acute phase sera, which indicated reinfection. In summary, it is not practicable to determine the true occurrence of sporadic hepatitis E. Nevertheless, it could be closely approximated by approach using a combination of all three acute markers.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65073]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Huang, S. J.,Zhang, X. F.,Jiang, H. M.,et al. Profile of Acute Infectious Markers in Sporadic Hepatitis E[J]. http://dx.doi.org/10.1371/journal.pone.0013560,2010.
APA	Huang, S. J..,Zhang, X. F..,Jiang, H. M..,Yan, Q. A..,Ai, X..,...&夏宁邵.(2010).Profile of Acute Infectious Markers in Sporadic Hepatitis E.http://dx.doi.org/10.1371/journal.pone.0013560.
MLA	Huang, S. J.,et al."Profile of Acute Infectious Markers in Sporadic Hepatitis E".http://dx.doi.org/10.1371/journal.pone.0013560 (2010).