Testicular Nuclear Receptor 4 (TR4) Regulates UV Light-induced Responses via Cockayne Syndrome B Protein-mediated Transcription-coupled DNA Repair

CORC > 厦门大学 > 生命科学－已发表论文

	Testicular Nuclear Receptor 4 (TR4) Regulates UV Light-induced Responses via Cockayne Syndrome B Protein-mediated Transcription-coupled DNA Repair
	Liu, Su ; Yan, Shian-Jang ; Lee, Yi-Fen ; Liu, Ning-Chun ; Ting, Huei-Ju ; Li, Gonghui ; Wu, Qiao ; Chen, Lu-Min ; Chang, Chawnshang ; Wu Q(吴乔)
刊名	http://dx.doi.org/10.1074/jbc.M111.259523
	2011-11-04
关键词	NUCLEOTIDE EXCISION-REPAIR ORPHAN RECEPTOR-4 OXIDATIVE STRESS GENE-EXPRESSION CELLULAR REPAIR MICE INDUCTION APOPTOSIS 8-HYDROXYADENINE DEGENERATION
英文摘要	National Institutes of Health [DK073414, CA127548]; Taiwan Department of Health Clinical Trial and Research Center of Excellence [DOH99-TD-B-111-004]; UV irradiation is one of the major external insults to cells and can cause skin aging and cancer. In response to UV light-induced DNA damage, the nucleotide excision repair (NER) pathways are activated to remove DNA lesions. We report here that testicular nuclear receptor 4 (TR4), a member of the nuclear receptor family, modulates DNA repair specifically through the transcription-coupled (TC) NER pathway but not the global genomic NER pathway. The level of Cockayne syndrome B protein (CSB), a member of the TC-NER pathway, is 10-fold reduced in TR4-deficient mouse tissues, and TR4 directly regulates CSB at the transcriptional level. Moreover, restored CSB expression rescues UV hypersensitivity of TR4-deficient cells. Together, these results indicate that TR4 modulates UV sensitivity by promoting the TC-NER DNA repair pathway through transcriptional regulation of CSB. These results may lead to the development of new treatments for UV light-sensitive syndromes, skin cancer, and aging.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/65009]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Liu, Su,Yan, Shian-Jang,Lee, Yi-Fen,et al. Testicular Nuclear Receptor 4 (TR4) Regulates UV Light-induced Responses via Cockayne Syndrome B Protein-mediated Transcription-coupled DNA Repair[J]. http://dx.doi.org/10.1074/jbc.M111.259523,2011.
APA	Liu, Su.,Yan, Shian-Jang.,Lee, Yi-Fen.,Liu, Ning-Chun.,Ting, Huei-Ju.,...&吴乔.(2011).Testicular Nuclear Receptor 4 (TR4) Regulates UV Light-induced Responses via Cockayne Syndrome B Protein-mediated Transcription-coupled DNA Repair.http://dx.doi.org/10.1074/jbc.M111.259523.
MLA	Liu, Su,et al."Testicular Nuclear Receptor 4 (TR4) Regulates UV Light-induced Responses via Cockayne Syndrome B Protein-mediated Transcription-coupled DNA Repair".http://dx.doi.org/10.1074/jbc.M111.259523 (2011).