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	Conservation of Dnmt1o cytosine methyltransferase in the marsupial Monodelphis domestica
	Ding, F. ; Patel, C. ; Ratnam, S. ; McCarrey, J. R. ; Chaillet, J. R. ; Ding F(丁凤)
	2003
关键词	methylation imprinting marsupial epigenetic opossum
英文摘要	Imprinted genes have been identified in both eutherian mammals and in marsupials. In eutherian species, there is a conservation of the imprinting process, both in terms of the genes imprinted and the epigenetic inheritance mechanism. In the mouse, the inheritance of gametic methylation patterns depends on an oocyte-derived isoform of the Dnmt1 (cytosine-5)-methyltransferase protein, Dnmt1o, which functions during preimplantation development to maintain methylation patterns on imprinted alleles. To determine if this component of genomic imprinting is also found in marsupials, Dnmt1 isoforms were examined in somatic cells and germ cells of the South American opossum Monodelphis domestica. There is a Dnmt1o protein in Monodelphis oocytes that is synthesized, as in the mouse, from a different transcript than the somatic Dnmt1 protein. Thus, an essential component of imprinting in eutherian mammals is found in a marsupial species, suggesting that marsupials and eutherian mammals imprint their genes with the same methylation-dependent mechanism. (C) 2003 Wiley-Liss, Inc.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/64915]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Ding, F.,Patel, C.,Ratnam, S.,et al. Conservation of Dnmt1o cytosine methyltransferase in the marsupial Monodelphis domestica[J],2003.
APA	Ding, F.,Patel, C.,Ratnam, S.,McCarrey, J. R.,Chaillet, J. R.,&丁凤.(2003).Conservation of Dnmt1o cytosine methyltransferase in the marsupial Monodelphis domestica..
MLA	Ding, F.,et al."Conservation of Dnmt1o cytosine methyltransferase in the marsupial Monodelphis domestica".(2003).

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