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	YAP oncogene overexpression supercharges colon cancer proliferation
	Avruch, Joseph ; Zhou, Dawang ; Zhou DW(周大旺) ; Bardeesy, Nabeel
	2012-03-15
关键词	YAP Hippo intestinal stem cell beta-catenin colon cancer liver cancer
英文摘要	The transcriptional co-activator YAP is an evolutionarily conserved regulator of organ size and progenitor cell proliferation. YAP is overexpressed at high frequency in many common human cancers and can directly drive cancer development in mouse models. YAP abundance and nuclear localization are negatively regulated by the Hippo kinase cascade, which, in epithelia, is activated by physiological cell-cell contact. Recent work in intestinal epithelium has established that YAP is constitutively inhibited by the Hippo pathway and entirely dispensable for normal development and homeostasis. YAP serves only in a standby capacity; should cell-cell contact be abrogated, as after intestinal damage, the loss of Hippo input permits increased YAP abundance and nuclear residence. In turn, YAP cooperates with beta-catenin to transactivate genes that promote stem cell expansion for epithelial repair. This interplay between overexpressed YAP and beta-catenin also drives proliferation of colon cancer cells. The dispensability of YAP in normal intestine makes YAP's expression or outputs attractive targets for cancer therapy.; NIH [DK17776, CA136567]; Sidney Kimmel Foundation for Cancer Research; Linda J. Verville Cancer Research Foundation; 111 Project of Education of China [B06016]; Fundamental Research Funds for the Central Universities of China [2010111079]; National Natural Science Foundation of China [81101503]; Natural Science Foundation of Fujian [2011J05096]
语种	英语
出版者	LANDES BIOSCIENCE
内容类型	期刊论文
源URL	[http://dx.doi.org/10.4161/cc.11.6.19453]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Avruch, Joseph,Zhou, Dawang,Zhou DW,et al. YAP oncogene overexpression supercharges colon cancer proliferation[J],2012.
APA	Avruch, Joseph,Zhou, Dawang,周大旺,&Bardeesy, Nabeel.(2012).YAP oncogene overexpression supercharges colon cancer proliferation..
MLA	Avruch, Joseph,et al."YAP oncogene overexpression supercharges colon cancer proliferation".(2012).

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