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	Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish
	Niu, Xubo ; Gao, Chuan ; Lo, Li Jan ; Luo, Yue ; Meng, Chunmei ; Hong, Jian ; Hong, Wanjin ; Hong WJ(洪万进) ; Peng, Jinrong
	2012-07-15
关键词	Sec13 COPII complex Digestive organs Liver development Zebrafish
英文摘要	The Sec13-Sec31 heterotetramer serves as the outer coat in the COPII complex, which mediates protein trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus. Although it has been studied in depth in yeast and cultured cells, the role of COPII in organogenesis in a multicellular organism has not. We report here that a zebrafish sec13(sq198) mutant, which exhibits a phenotype of hypoplastic digestive organs, has a mutation in the sec13 gene. The mutant gene encodes a carboxyl-terminus-truncated Sec13 that loses its affinity to Sec31a, which leads to disintegration of the ER structure in various differentiated cells in sec13(sq198), including chondrocytes, intestinal epithelial cells and hepatocytes. Disruption of the ER structure activates an unfolded protein response that eventually causes the cells to undergo cell-cycle arrest and cell apoptosis, which arrest the growth of developing digestive organs in the mutant. Our data provide the first direct genetic evidence that COPII function is essential for the organogenesis of the digestive system. (C) 2012 Elsevier Inc. All rights reserved.; National Natural Science Foundation of China [30825025]; "973 Program" [2012CB944500]; Agency for Science, Technology and Research in Singapore
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1016/j.ydbio.2012.05.004]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Niu, Xubo,Gao, Chuan,Lo, Li Jan,et al. Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish[J],2012.
APA	Niu, Xubo.,Gao, Chuan.,Lo, Li Jan.,Luo, Yue.,Meng, Chunmei.,...&Peng, Jinrong.(2012).Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish..
MLA	Niu, Xubo,et al."Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish".(2012).

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