QQ客服 官方微博 反馈留言

	EFFECT OF TRIBUTYLTIN ON TESTICULAR DEVELOPMENT IN SEBASTISCUS MARMORATUS AND THE MECHANISM INVOLVED
	Zhang, Jiliang ; Zhang JL(张纪亮) ; Zuo, Zhenghong ; Zuo ZH(左正宏) ; He, Chengyong ; Cai, Jiali ; Wang, Yuqing ; Chen, Yixin ; Chen YX(陈奕欣) ; Wang, Chonggang ; Wang ZG(王重刚)
	2009
关键词	Tributyltin Testis Lipid Estrogen receptor Sertoli cell
英文摘要	Organotin compounds, such as tributyltin (TBT), that have been used as antifouling biocides can induce masculinization in female mollusks. However, few studies addressing the effects of TBT on fishes have been reported. The present study was conducted to investigate the effects of TBT at environmentally relevant concentrations (1, 10, and 100 ng/L) on testicular development in Sebastiscus marmoratus and to gain insight into its mechanism of action. After exposure for 48 d, the gonadosomatic index had decreased in a dose-dependent manner. Although the testosterone levels in the testes were elevated and the 17 beta-estradiol levels were decreased, spermatogenesis was suppressed. Moreover, gamma-glutamyl transpeptidase activity (which is used as a Sertoli cell marker) was decreased in a dose-dependent manner after TBT exposure, and serious interstitial fibrosis was observed in the interlobular septa of the testes in the 100 ng/L TBT test group. Increases in the retinoid X receptors and peroxisome proliferator activated receptor gamma expression and the progressive enlargement of lipid droplets in the testes were observed after TBT exposure. Estrogen receptor alpha levels in the testes of the fish exposed to TBT decreased in a dose-dependent manner. The reduction of estrogen receptor alpha mRNA resulted from the decrease of 17 beta-estradiol levels, and the progressive enlargement of lipid droplets may have contributed to the dysfunction of the Sertoli cells, which then disrupted spermatogenesis.; National Natural Science Foundation of China [20777061]
语种	英语
出版者	SETAC PRESS
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1897/08-347.1]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Zhang, Jiliang,Zhang JL,Zuo, Zhenghong,et al. EFFECT OF TRIBUTYLTIN ON TESTICULAR DEVELOPMENT IN SEBASTISCUS MARMORATUS AND THE MECHANISM INVOLVED[J],2009.
APA	Zhang, Jiliang.,张纪亮.,Zuo, Zhenghong.,左正宏.,He, Chengyong.,...&王重刚.(2009).EFFECT OF TRIBUTYLTIN ON TESTICULAR DEVELOPMENT IN SEBASTISCUS MARMORATUS AND THE MECHANISM INVOLVED..
MLA	Zhang, Jiliang,et al."EFFECT OF TRIBUTYLTIN ON TESTICULAR DEVELOPMENT IN SEBASTISCUS MARMORATUS AND THE MECHANISM INVOLVED".(2009).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。