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	New Polyketides from Endophytic Diaporthe sp XZ-07
	Yuan, Lin ; Lin, Xiang ; Zhao, Pei-Ji ; Ma, Juan ; Huang, Yao-Jian ; Huang YJ(黄耀坚) ; Shen, Yue-Mao ; Shen YM(沈月毛)
	2009
英文摘要	Four new polyketides, namely rel-(2R,3S,4R,5R)-4-ethyltetrahydro-3-methyl-5-propylfuran-2,3-diol (1), methyl 5-[(1R)-1-hydroxyethyl]-gamma-oxofuran-2-butanoate (2), butyl 5-[(1R)-1-hydroxyethyl]-gamma-oxofuran-2-butanoate (3), and 3,4-dihydro-5'-[(1R)-1-hydroxyethyl][2,2'-bifuran]-5(2H)-one (4), together with three known ones, 5-[(1R)-1-hydroxethyl)-gamma-oxofuran-2-butanoic acid (5), phomopsolide B (6), and (2S,3S)-3,6-dihydro-6-oxo-2-[(1E)-2-{(4S,5S)-2,2,5-trimethyl-1,3-dioxolan-4-yl]ethenyl)-2H-pyran-3-yl (2E)-2-methylbut-2-enoate (7), were isolated from the submerged cultures of the endophytic fungal strain Diaporthe sp. XZ-07 of Camptotheca acuminate. The structures of the new compounds were established by 1D- and 2D-NMR and MS data and by Mosher's method. Compound 6 significantly inhibited the growth of human-tumor HeLa cells with an IC50 of 5.7 mu g/ml by the MTT assay (MTT = 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide).
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1002/hlca.200800416]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Yuan, Lin,Lin, Xiang,Zhao, Pei-Ji,et al. New Polyketides from Endophytic Diaporthe sp XZ-07[J],2009.
APA	Yuan, Lin.,Lin, Xiang.,Zhao, Pei-Ji.,Ma, Juan.,Huang, Yao-Jian.,...&沈月毛.(2009).New Polyketides from Endophytic Diaporthe sp XZ-07..
MLA	Yuan, Lin,et al."New Polyketides from Endophytic Diaporthe sp XZ-07".(2009).

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