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	Anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells (Retracted article. See vol. 38, pg. 869, 2009)
	Taechowisan, Thongchai（Department of Microbiology, Faculty of Science, Silpakorn University, Nakorn, Pathom, Thailand） ; Tuntiwachwuttikul, Pittaya（Department of Microbiology, Faculty of Science, Silpakorn University, Nakorn, Pathom, Thailand） ; Lu, Chunhua ; Lu CH(鲁春华) ; Shen, Yuemao ; Shen YM(沈月毛) ; Lumyong, Saisamorn（Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand） ; Taylor, Walter C.（School of Chemistry, University of Sydney, NSW, Australia）
	2007
关键词	4-arylcoumarins anti-inflammatory activity endophytic Streptomyces murine macrophage RAW 264.7 cells
英文摘要	This research was undertaken to test the in vitro anti-inflammatory action of 5,7,4'-trimethoxy-4-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. The effects of the two coumarins were investigated on the formation of NO, PGE(2), and TNF-alpha and also on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar effect was also observed when LPS-induced PGE(2) release and COX-2 expression were tested. The inhibitory effects were shown in concentration-dependent manners. The 5,7,4'-Trimethoxy-4-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin also mildly but significantly reduced the formation of TNF-alpha.
语种	英语
出版者	TAYLOR & FRANCIS INC
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1080/08820130600992115]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Taechowisan, Thongchai,Tuntiwachwuttikul, Pittaya,Lu, Chunhua,et al. Anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells (Retracted article. See vol. 38, pg. 869, 2009)[J],2007.
APA	Taechowisan, Thongchai.,Tuntiwachwuttikul, Pittaya.,Lu, Chunhua.,鲁春华.,Shen, Yuemao.,...&Taylor, Walter C..(2007).Anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells (Retracted article. See vol. 38, pg. 869, 2009)..
MLA	Taechowisan, Thongchai,et al."Anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells (Retracted article. See vol. 38, pg. 869, 2009)".(2007).

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