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	The hemagglutinin structure of an avian H1N1 influenza A virus
	Lin, Tianwei ; Lin TW(林天伟) ; Li, Anzhang ; Zhang, Qian ; Wu, Caiming ; Zhang, Rongfu ; Cai, Qixu ; Song, Wenjun ; Yuen, Kwok-Yung ; Wang, Gengyan
	2009
关键词	Influenza H1N1 Hemagglutinin Receptor Structure
英文摘要	The interaction between hemagglutinin (HA) and receptors is a kernel in the study of evolution and host adaptation of H1N1 influenza A viruses. The notion that the avian HA is associated with preferential specificity for receptors with Sia alpha 2,3Gal glycosidic linkage over those with Sia alpha 2,6Gal linkage is not all consistent with the available data on H1N1 viruses. By x-ray crystallography, the HA structure of an avian H1N1 influenza A virus, as well as its complexes with the receptor analogs, was determined. The structures revealed no preferential binding of avian receptor analogs over that of the human analog, suggesting that the HA/receptor binding might not be as stringent as is commonly believed in determining the host receptor preference for some subtypes of influenza viruses, such as the H1N1 viruses. The structure also showed difference in glycosylation despite the preservation of related sequences, which may partly contribute to the difference between structures of human and avian origin. (C) 2009 Elsevier Inc. All rights reserved.; National Science Foundation of China [30870479]; 111 Project of China [B06016]; Providence Foundation Limited ; Research Fund for Infections Diseases of Hong Kong SAR ; Li Ka Shing Foundation
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.virol.2009.06.028]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Lin, Tianwei,Lin TW,Li, Anzhang,et al. The hemagglutinin structure of an avian H1N1 influenza A virus[J],2009.
APA	Lin, Tianwei.,林天伟.,Li, Anzhang.,Zhang, Qian.,Wu, Caiming.,...&Wang, Gengyan.(2009).The hemagglutinin structure of an avian H1N1 influenza A virus..
MLA	Lin, Tianwei,et al."The hemagglutinin structure of an avian H1N1 influenza A virus".(2009).

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