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	DNA hypomethylation induced by tributyltin, triphenyltin, and a mixture of these in Sebastiscus marmoratus liver
	Wang, Yuqing ; Wang, Chonggang ; Wang ZG(王重刚) ; Zhang, Jiliang ; Chen, Yixin ; Chen YX(陈毅歆) ; Zuo, Zhenghong ; Zuo ZH(左正宏)
	2009
关键词	Triphenyltin DNA hypomethylation Liver Sebastiscus marmoratus
英文摘要	Tributyltin (TBT) and triphenyltin (TPT) coexist in freshwater and marine environments. However. the effects of TBT, TPT, and a mixture of the two on DNA methylation in marine fish livers and the mechanism involved remain to be elucidated. Previous study have proved that abnormal methylation patterns are induced by the balance of transmethylation reaction including the tissue level of S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) or the activity of DNA (cytosine-5) methyltransferase 1 (DNMT1). Therefore, in the present study, we assessed their ability to cause hepatic DNA hypomethylation in Sebastiscus marmoratus liver and the related mechanism. The results showed that TBT, TPT, and a mixture of the two significantly induced DNA hypomethylation in the fish livers in a dose-dependent manner. Using Pearson correlation coefficient analysis, we identified strong linear correlations between S-adenosylhomocysteine, S-adenosylmethionine, or the SAM to SAH ratio and the hepatic genome-wide 5-methylcytosine content of the DNA, but no correlation between the latter and the DNMT1 expression level. It is therefore proposed that the organotins hypomethylation induced in the marine fish livers was due to altering the balance of the substrate and the product in transmethylation reactions. (C) 2009 Elsevier B.V. All rights reserved.; National Natural Science Foundation, China [40776067]
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1016/j.aquatox.2009.06.008]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Wang, Yuqing,Wang, Chonggang,Wang ZG,et al. DNA hypomethylation induced by tributyltin, triphenyltin, and a mixture of these in Sebastiscus marmoratus liver[J],2009.
APA	Wang, Yuqing.,Wang, Chonggang.,王重刚.,Zhang, Jiliang.,Chen, Yixin.,...&左正宏.(2009).DNA hypomethylation induced by tributyltin, triphenyltin, and a mixture of these in Sebastiscus marmoratus liver..
MLA	Wang, Yuqing,et al."DNA hypomethylation induced by tributyltin, triphenyltin, and a mixture of these in Sebastiscus marmoratus liver".(2009).

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