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	ES proteins analysis of Angiostrongylus cantonensis: products of the potential parasitism genes?
	Chen, Xiaobin（Shanghai Jiao Tong Univ） ; Luo, Damin ; Luo DM(罗大民) ; Wang, Yinan ; Fang, Wenzhen ; Fang WZ(方文珍) ; Xu, Shisan ; Ni, Fang ; Zhang, Shaolei ; Zhang, Shaolei
	2010
英文摘要	The expressed sequence tags (ESTs) of Angiostrongylus cantonensis were analyzed in an attempt to gain further insight into its genomic expression patterns. A total of 1,277 ESTs of A. cantonensis were randomly downloaded from NCBI databank. ESTs were analyzed and annotated using Blastx. The result showed that there were 60 ESTs had no match to any of the proteins and gene sequences in the published databases, and 695 ESTs score more than 80. According to the function, the identified 695 ESTs could be grouped into 13 categories related to metabolism, cellular development, immune evasion, host-parasite interactions, and so on. Among them, 65 (9.4%) were proteases and protease inhibitors, represented 19 potential proteases and protease inhibitors genes; 42 (6.0%) were allergens or antigens, represented 15 potential antigens/allergens genes. SignalP analysis was applied to the 19 putative proteases and protease inhibitors and the 15 antigens/allergens protein sequences to identify the potential signal peptides and anchors. The result demonstrated that there were ten putative proteins had N-terminal signal peptides and three had signal anchors, these putative excretory/secretory proteins might be the products of potential parasitism genes which played an important role in the adaptation of A. cantonensis to a parasitism life. These parasitism genes and proteins identified are expected to become potential targets for future research on anti-A. cantonensis drugs; moreover, the resulting genetic information is useful in elucidating the mechanisms of parasitism of A. cantonensis.; Science and Technology Planning Project of Fujian Province [2008N2005]
语种	英语
出版者	SPRINGER
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.1007/s00436-010-1751-z]
专题	生命科学－已发表论文
推荐引用方式 GB/T 7714	Chen, Xiaobin,Luo, Damin,Luo DM,et al. ES proteins analysis of Angiostrongylus cantonensis: products of the potential parasitism genes?[J],2010.
APA	Chen, Xiaobin.,Luo, Damin.,罗大民.,Wang, Yinan.,Fang, Wenzhen.,...&Zhang, Shaolei.(2010).ES proteins analysis of Angiostrongylus cantonensis: products of the potential parasitism genes?..
MLA	Chen, Xiaobin,et al."ES proteins analysis of Angiostrongylus cantonensis: products of the potential parasitism genes?".(2010).

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