Comparison of non-covalent interactions between a series of N-phosphoryl dipeptide or methyl esters and cytochrome C by electrospray ionization mass spectrometry | |
Qiang, Liming ; Dong, Xuru ; L眉, Mingxiu ; Lu, Kui ; Zhao, Yufe ; Cao, Shuxia ; Zhao YF(赵玉芬) | |
2012 | |
关键词 | Amino acids Aromatic compounds Esters Industrial applications Industrial research Mass spectrometry Peptides |
英文摘要 | Conference Name:2011 SSITE International Conference on Future Material Research and Industry Application, FMRIA 2011. Conference Address: Macau, China. Time:December 1, 2011 - December 2, 2011.; The non-covalent interaction between a series of N-phosphoryl dipeptides (or methyl esters) (DPP) and cytochrome C was studied by ESI-MS. The function of different groups in DPP and binding sites of protein were investigated. The results revealed that hydroxyl and aromatic ring in DPP were both important group for the interaction, and aromatic ring had double functions on the interaction. In addition, the molecular size, flexibility and steric hindrance showed obvious effects on the interaction, while, the chirality, sequence and length of carbon chains (changing 1-2C) of amino acid residue in DPP showed little effects on the interaction under the experimental conditions. The results provide some useful information and theoretical basis for the molecular design of peptide drugs. 漏 (2012) Trans Tech Publications, Switzerland. |
语种 | 英语 |
出处 | http://dx.doi.org/10.4028/www.scientific.net/AMR.455-456.483 |
出版者 | Trans Tech Publications |
内容类型 | 其他 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/85416] |
专题 | 化学化工-会议论文 |
推荐引用方式 GB/T 7714 | Qiang, Liming,Dong, Xuru,L眉, Mingxiu,et al. Comparison of non-covalent interactions between a series of N-phosphoryl dipeptide or methyl esters and cytochrome C by electrospray ionization mass spectrometry. 2012-01-01. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论