Generation of gold carbenes in water: Efficient intermolecular trapping of the α-oxo gold carbenoids by indoles and anilines

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	Generation of gold carbenes in water: Efficient intermolecular trapping of the α-oxo gold carbenoids by indoles and anilines
	Li, Long ; Shu, Chao ; Zhou, Bo ; Yu, Yong-Fei ; Xiao, Xin-Yu ; Ye, Long-Wu ; Ye LW(叶龙武)
刊名	http://dx.doi.org/10.1039/c4sc00983e
	2014
关键词	Aniline Catalysis Chemical compounds Hydrocarbons Reaction intermediates
英文摘要	The efficient intermolecular reaction of gold carbene intermediates, generated via gold-catalyzed alkyne oxidation, with indoles and anilines has been realized in aqueous media. Importantly, it was revealed for the first time that water could dramatically suppress the undesired over-oxidation, providing a general and practical solution to the problem of over-oxidation in gold-catalyzed intermolecular alkyne oxidation with external nucleophiles. This strategy was successfully applied to the formal synthesis of the Pfizer's chiral endothelin antagonist UK-350,926. ? 2014 the Partner Organisations.
语种	英语
出版者	Royal Society of Chemistry
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89728]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Li, Long,Shu, Chao,Zhou, Bo,et al. Generation of gold carbenes in water: Efficient intermolecular trapping of the α-oxo gold carbenoids by indoles and anilines[J]. http://dx.doi.org/10.1039/c4sc00983e,2014.
APA	Li, Long.,Shu, Chao.,Zhou, Bo.,Yu, Yong-Fei.,Xiao, Xin-Yu.,...&叶龙武.(2014).Generation of gold carbenes in water: Efficient intermolecular trapping of the α-oxo gold carbenoids by indoles and anilines.http://dx.doi.org/10.1039/c4sc00983e.
MLA	Li, Long,et al."Generation of gold carbenes in water: Efficient intermolecular trapping of the α-oxo gold carbenoids by indoles and anilines".http://dx.doi.org/10.1039/c4sc00983e (2014).