Substitution of gadolinium ethylenediaminetetraacetate with phosphites: towards gadolinium deposit in nephrogenic systemic fibrosis

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	Substitution of gadolinium ethylenediaminetetraacetate with phosphites: towards gadolinium deposit in nephrogenic systemic fibrosis
	Gao, Song ; Chen, Mao-Long ; Zhou, Zhao-Hui ; Zhou CH(周朝晖)
刊名	http://dx.doi.org/10.1039/c3dt52015c
	2014
关键词	MRI CONTRAST AGENTS COMPLEXES DERMOPATHY DESIGN
英文摘要	Ministry of Science Technology [2010CB732303]; National Science Foundation of China [20571061]; PCSIRIC [IRT 1036]; In neutral media, reactions of gadolinium ethylenediaminetetraacetates with phosphorous acid result in the formation of the mixed-ligand polymeric complex K-3n[Gd(EDTA)(HPO3)](n)center dot 7nH(2)O (1) and dimeric complex Na-6[Gd-2(EDTA)(2)(HPO3)(2)]center dot 2.5NaCl center dot 21H(2)O (2) (H(4)EDTA = ethylenediaminetetraacetic acid) in warm solution. Further substitution with citric acid gives the monomeric gadolinium citrate with EDTA (NH4)(2)Na[Gd(EDTA)(H(2)cit)]center dot 4H(2)O (3). The compounds were characterized by elemental analysis, single crystal X-ray diffraction, FT-IR, ESI-MS and thermogravimetric analysis. Structural analysis indicates that three coordinated water molecules in the gadolinium ethylenediaminetetraacetate trihydrates are replaced by phosphite ions (HPO32-) in the compounds 1 and 2. Gadolinium atoms are octa-coordinated by EDTA and the phosphite ion, the latter links adjacent Gd-EDTA units to generate an infinite one-dimensional chain in compound 1 and a dimeric octatomic ring in 2. In complex 3, coordinated water molecules were substituted by the alpha-hydroxy, alpha-carboxy and beta-carboxy groups of citrate. Citrate is favourable for inhibiting the formation of Gd-EDTA phosphite. All the complexes are very easily soluble in water. The solution behavior of the isostructural lanthanum complexes was probed with C-13 and P-31 NMR spectra in D2O for comparison. ESI-MS analysis and recrystallization proved that complexes 1 and 2 dissociate to the monomeric unit of Gd-EDTA and free HPO32- in aqueous solution. Substitutions of gadolinium ethylenediaminetetraacetates to 1 and 2 are attributed to be the cause of nephrogenic systemic fibrosis in some way.
语种	英语
出版者	ROYAL SOC CHEMISTRY
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89502]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Gao, Song,Chen, Mao-Long,Zhou, Zhao-Hui,et al. Substitution of gadolinium ethylenediaminetetraacetate with phosphites: towards gadolinium deposit in nephrogenic systemic fibrosis[J]. http://dx.doi.org/10.1039/c3dt52015c,2014.
APA	Gao, Song,Chen, Mao-Long,Zhou, Zhao-Hui,&周朝晖.(2014).Substitution of gadolinium ethylenediaminetetraacetate with phosphites: towards gadolinium deposit in nephrogenic systemic fibrosis.http://dx.doi.org/10.1039/c3dt52015c.
MLA	Gao, Song,et al."Substitution of gadolinium ethylenediaminetetraacetate with phosphites: towards gadolinium deposit in nephrogenic systemic fibrosis".http://dx.doi.org/10.1039/c3dt52015c (2014).