Synthesis and characterization of novel chiral bidentate P,N-containing ligands and ruthenium(II) complex The application in asymmetric transfer hydrogenation of ketones

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	Synthesis and characterization of novel chiral bidentate P,N-containing ligands and ruthenium(II) complex The application in asymmetric transfer hydrogenation of ketones
	Zeng, Li ; Wu, Fang ; Li, Yan-Yun ; Dong, Zhen-Rong ; Gao, Jing-Xing ; Li YY(李岩云) ; Gao JX(高景星)
刊名	http://dx.doi.org/10.1016/j.jorganchem.2014.04.007
	2014-07-15
关键词	ENANTIOSELECTIVE CONJUGATE ADDITION AROMATIC KETONES PHOSPHORUS LIGANDS IRIDIUM CATALYST IRON COMPLEXES REDUCTION OLEFINS CYCLOPROPANATION ALCOHOLS RHODIUM
英文摘要	National Natural Science Foundation of China [21173176]; Program for Changjiang Scholars and Innovative Research Team in University [IRT1036]; Novel chiral bidentate P,N-containing ligands have been easily synthesized by Schiff-base condensation of o-(diphenylphosphino) benzaldehyde and modified chiral diamine, (R,R)-2-(2,5-dimethyl-pyrrol-1-yl)-cyclohexylamine, further reduction with NaBH4. The chiral ruthenium(II) complex could be successfully prepared from the reaction between chiral bidentate aminophosphine ligand and RuCl2(PPh3)(3). The chiral bidentate P,N-containing ligands and ruthenium(II) complex were fully characterized by NMR, IR, HRMS and single-crystal X-ray diffraction studies. In the presence of KOH, the asymmetric transfer hydrogenation (ATH) of various ketones catalyzed by the chiral ruthenium(II) complex proceeded smoothly under mild conditions, affording corresponding chiral secondary alcohols with up to 99% conversion and up to 60% ee. Additive such as NH4I was found to be helpful to promoting the enantioselectivity. (C) 2014 Elsevier B. V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE SA
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89247]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Zeng, Li,Wu, Fang,Li, Yan-Yun,et al. Synthesis and characterization of novel chiral bidentate P,N-containing ligands and ruthenium(II) complex The application in asymmetric transfer hydrogenation of ketones[J]. http://dx.doi.org/10.1016/j.jorganchem.2014.04.007,2014.
APA	Zeng, Li.,Wu, Fang.,Li, Yan-Yun.,Dong, Zhen-Rong.,Gao, Jing-Xing.,...&高景星.(2014).Synthesis and characterization of novel chiral bidentate P,N-containing ligands and ruthenium(II) complex The application in asymmetric transfer hydrogenation of ketones.http://dx.doi.org/10.1016/j.jorganchem.2014.04.007.
MLA	Zeng, Li,et al."Synthesis and characterization of novel chiral bidentate P,N-containing ligands and ruthenium(II) complex The application in asymmetric transfer hydrogenation of ketones".http://dx.doi.org/10.1016/j.jorganchem.2014.04.007 (2014).