Cancer therapy improvement with mesoporous silica nanoparticles combining photodynamic and photothermal therapy

CORC > 厦门大学 > 化学化工－已发表论文

	Cancer therapy improvement with mesoporous silica nanoparticles combining photodynamic and photothermal therapy
	Zhao, Z. X. ; Huang, Y. Z. ; Shi, S. G. ; Tang, S. H. ; Li, D. H. ; Chen, X. L. ; Chen XL(陈小兰)
刊名	http://dx.doi.org/10.1088/0957-4484/25/28/285701
	2014-07-18
关键词	PHOTOSENSITIZERS FLUORESCENT RADIATION DELIVERY AGENTS
英文摘要	National Natural Science Foundation of China [21101131]; National Basic Research Foundation (973) of China [2014CB932004]; Natural Science Foundation of Fujian Province [2012J01056]; Fundamental Research Funds for the Central Universities [2010121015]; open project grant from State Key Laboratory of Chemo/Biosensing and Chemometrics [2013009]; Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry; In this work, we develop novel mesoporous silica composite nanoparticles (hm-SiO2(AlC4Pc)@Pd) for the co-delivery of photosensitizer (PS) tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc) and small Pd nanosheets as a potential dual carrier system to combine photodynamic therapy (PDT) with photothermal therapy (PTT). In the nanocomposite, PS AlC4Pc was covalently conjugated to a mesoporous silica network, and small Pd nanosheets were coated onto the surface of mesoporous silica by both coordination and electrostatic interaction. Since small Pd nanosheets and AlC4Pc display matched maximum absorptions in the 600-800 nm near-infrared (NIR) region, the fabricated hm-SiO2(AlC4Pc)@Pd nanocomposites can generate both singlet oxygen and heat upon 660 nm single continuous wavelength (CW) laser irradiation. In vitro results indicated that the cell-killing efficacy by simultaneous PDT/PTT treatment using hm-SiO2(AlC4Pc)@Pd was higher than PDT or PTT treatment alone after exposure to a 660 nm CW-NIR laser.
语种	英语
出版者	IOP PUBLISHING LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/89246]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Zhao, Z. X.,Huang, Y. Z.,Shi, S. G.,et al. Cancer therapy improvement with mesoporous silica nanoparticles combining photodynamic and photothermal therapy[J]. http://dx.doi.org/10.1088/0957-4484/25/28/285701,2014.
APA	Zhao, Z. X..,Huang, Y. Z..,Shi, S. G..,Tang, S. H..,Li, D. H..,...&陈小兰.(2014).Cancer therapy improvement with mesoporous silica nanoparticles combining photodynamic and photothermal therapy.http://dx.doi.org/10.1088/0957-4484/25/28/285701.
MLA	Zhao, Z. X.,et al."Cancer therapy improvement with mesoporous silica nanoparticles combining photodynamic and photothermal therapy".http://dx.doi.org/10.1088/0957-4484/25/28/285701 (2014).