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	Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo
	Duong, B. H. ; Tian, H. ; Ota, T. ; Completo, G. ; Han, S. F. ; Vela, J. L. ; Ota, M. ; Kubitz, M. ; Bovin, N. ; Paulson, J. ; Nemazee, D. ; Han SF(韩守法)
	2010
关键词	TYROSINE-PHOSPHATASE 1C SIALIC-ACID NEGATIVE REGULATOR INHIBITORY RECEPTORS SIGNAL-TRANSDUCTION CD22-DEFICIENT MICE LYMPHOCYTE SURVIVAL AUTOIMMUNE-DISEASE ANTIBODY-RESPONSES TRANSGENIC MICE
英文摘要	Autoreactive B lymphocytes first encountering self-antigens in peripheral tissues are normally regulated by induction of anergy or apoptosis. According to the "two-signal" model, antigen recognition alone should render B cells tolerant unless T cell help or inflammatory signals such as lipopolysaccharide are provided. However, no such signals seem necessary for responses to T-independent type 2 (TI-2) antigens, which are multimeric antigens lacking T cell epitopes and Toll-like receptor ligands. How then do mature B cells avoid making a TI-2-like response to multimeric self-antigens? We present evidence that TI-2 antigens decorated with ligands of inhibitory sialic acid-binding Ig-like lectins (siglecs) are poorly immunogenic and can induce tolerance to subsequent challenge with immunogenic antigen. Two siglecs, CD22 and Siglec-G, contributed to tolerance induction, preventing plasma cell differentiation or survival. Although mutations in CD22 and its signaling machinery have been associated with dysregulated B cell development and autoantibody production, previous analyses failed to identify a tolerance defect in antigen-specific mutant B cells. Our results support a role for siglecs in B cell self-/nonself-discrimination, namely suppressing responses to self-associated antigens while permitting rapid "missing self"-responses to unsialylated multimeric antigens. The results suggest use of siglec ligand antigen constructs as an approach for inducing tolerance.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/64283]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Duong, B. H.,Tian, H.,Ota, T.,et al. Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo[J],2010.
APA	Duong, B. H..,Tian, H..,Ota, T..,Completo, G..,Han, S. F..,...&韩守法.(2010).Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo..
MLA	Duong, B. H.,et al."Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo".(2010).

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