Multi-functional core-shell hybrid nanogels for pH-dependent magnetic manipulation, fluorescent pH-sensing, and drug delivery

CORC > 厦门大学 > 化学化工－已发表论文

	Multi-functional core-shell hybrid nanogels for pH-dependent magnetic manipulation, fluorescent pH-sensing, and drug delivery
	Wu, Weitai ; Shen, Jing ; Gai, Zheng ; Hong, Kunlun ; Banerjee, Probal ; Zhou, Shuiqin ; Wu WT(吴伟泰)
刊名	http://dx.doi.org/10.1016/j.biomaterials.2011.08.082
	2011-12
关键词	NANOPARTICLES MICROGELS NANOCRYSTALS KINETICS PROBES TUMORS
英文摘要	US Agency for International Development [PGA-P280422]; Xiamen University; Scientific User Facilities Division, Department of Energy of the US; Remotely optical sensing and drug delivery using an environmentally-guided magnetically-driven hybrid nanogel particle could allow for medical diagnostics and treatment. Such multifunctional hybrid nanogels (<200 nm) were prepared through the first synthesis of magnetic Ni NPs, followed by a moderate growth of fluorescent metallic Ag on the surface of Ni NPs, and then a coverage of a pH-responsive copolymer gel shell of poly(ethylene glycol-co-methacrylic acid) [p(EG-MAA)] onto the Ni-Ag bimetallic NP cores (18 +/- 5 nm). The introduction of the pH-responsive p(EG-MAA) gel shell onto the magnetic and fluorescent Ni-Ag NPs makes the polymer-bound Ni-Ag NPs responsive to pH over the physiologically important range 5.0-7.4. The hybrid nanogels can adapt to surrounding pH and regulate the sensitivity in response to external magnetic field (such as a small magnet of 0.1 T), resulting in the accumulation of the hybrid nanogels within the duration from hours to a few seconds as the pH value decreases from 7.4 to 5.0. The pH-dependent magnetic response characteristic of the hybrid nanogels were further integrated with the pH change to fluorescent signal transduction and pH-regulated anticancer drug (a model drug 5-fluorouracil) delivery functions. The hybrid nanogels can overcome cellular barriers to enter the intracellular region and light up the mouse melanoma B16F10 cells. The multiple responsive hybrid nanogel that can be manipulated in tandem endogenous and exogenous activation should enhance our ability to address the complexity of biological systems. (C) 2011 Elsevier Ltd. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/61459]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Wu, Weitai,Shen, Jing,Gai, Zheng,et al. Multi-functional core-shell hybrid nanogels for pH-dependent magnetic manipulation, fluorescent pH-sensing, and drug delivery[J]. http://dx.doi.org/10.1016/j.biomaterials.2011.08.082,2011.
APA	Wu, Weitai.,Shen, Jing.,Gai, Zheng.,Hong, Kunlun.,Banerjee, Probal.,...&吴伟泰.(2011).Multi-functional core-shell hybrid nanogels for pH-dependent magnetic manipulation, fluorescent pH-sensing, and drug delivery.http://dx.doi.org/10.1016/j.biomaterials.2011.08.082.
MLA	Wu, Weitai,et al."Multi-functional core-shell hybrid nanogels for pH-dependent magnetic manipulation, fluorescent pH-sensing, and drug delivery".http://dx.doi.org/10.1016/j.biomaterials.2011.08.082 (2011).