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	Preparation and photodynamic therapy application of NaYF4:Yb, Tm-NaYF4:Yb, Er multifunctional upconverting nanoparticles
	Xiaolan Chen ; Chen XL(陈小兰) ; Zengxia Zhao ; Zhao ZX(赵增侠) ; Mengying Jiang ; Daiping Que ; Saige Shi ; Shi SG(师赛鸽) ; Nanfeng Zheng ; Zheng NF(郑南峰)
	2013-04
关键词	UP-CONVERSION FLUORESCENCE RARE-EARTH NANOCRYSTALS DRUG-DELIVERY CANCER-CELLS MONODISPERSE NANOCRYSTALS MAGNETIC-RESONANCE OPTICAL-PROPERTIES SINGLET OXYGEN SHELL CORE
英文摘要	E-mail Addresses: chenxl@xmu.edu.cn; nfzheng@xmu.edu.cn; The preparation, characterization and application of NaYF4:Yb3+, Tm3+-NaYF4:Yb3+, Er3+ core-shell upconversion nanocrystals (UCNPs) with multiple emission peaks (e.g. 539, 654 and 802 nm) have been demonstrated in this work. The monodisperse nanocrystals were prepared via a modified thermal decomposition synthesis. The resulting UCNPs were similar to 31 nm in diameter with the lanthanide ions Tm3+ and Er3+ doped in the core and the shell, respectively. Under the laser diode excitation at 980 nm, these core-shell nanocrystals give strong upconversion emissions from the visible to near-infrared (NIR) region. By coating a PEG-phospholipid (PP) layer on the surface of the nanocrystals, the as-prepared UCNPs were favorably endowed with good water solubility for the potential biological applications. Here, a photosensitizer drug of Chlorin e6 (Ce6), which has maximum absorption that overlaps with the red emission of UCNPs, was loaded on these PP-coated UCNPs (UCNP@PP) by physical adsorption. The activity of the Ce6-loaded UCNP@PP (UCNP@PP-Ce6) in photodynamic therapy of cancer cells in vitro has been fully investigated in this work. Our results indicated that these multifunctional UCNP@PP-Ce6 nanoparticles have efficient NIR-to-NIR upconversion luminescence and photodynamic therapy capabilities, which could be potentially employed as a theranostic platform for cancer treatment.; National Natural Science Foundation of China 21101131 21021061 20925103 Natural Science Foundation of Fujian Province 2012J01056 Fundamental Research Funds for the Central Universities 2010121015 Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry NFFTBS J1210014
语种	英语
出版者	ROYAL SOC CHEMISTRY
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/55410]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Xiaolan Chen,Chen XL,Zengxia Zhao,et al. Preparation and photodynamic therapy application of NaYF4:Yb, Tm-NaYF4:Yb, Er multifunctional upconverting nanoparticles[J],2013.
APA	Xiaolan Chen.,陈小兰.,Zengxia Zhao.,赵增侠.,Mengying Jiang.,...&郑南峰.(2013).Preparation and photodynamic therapy application of NaYF4:Yb, Tm-NaYF4:Yb, Er multifunctional upconverting nanoparticles..
MLA	Xiaolan Chen,et al."Preparation and photodynamic therapy application of NaYF4:Yb, Tm-NaYF4:Yb, Er multifunctional upconverting nanoparticles".(2013).

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