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	SmI2-Mediated Coupling of Nitrones and tert-Butanesulfinyl Imines with Allenoates: Synthesis of beta-Methylenyl-gamma-lactams and Tetramic Acids
	Xu, Chu-Pei ; Huang, Pei-Qiang ; Huang PQ(黄培强) ; Py, Sandrine
	2012-04-20
关键词	CONCISE ASYMMETRIC-SYNTHESIS ETHYNYL SUBSTITUTED SERINE SAMARIUM DIIODIDE CHIRAL NITRONES (+)-HYACINTHACINE A(2) RADICAL CYCLIZATION CONJUGATE ADDITION VICINAL DIAMINES FORMAL SYNTHESIS TETRONIC ACIDS
英文摘要	Nitrones and tert-butanesulfinyl imines undergo conjugate addition to alkyl allenoates under SmI2-mediated reductive coupling conditions to produce novel beta-methylenyl-substituted gamma-amino esters. The latter were readily transformed into the corresponding beta-methylenyl-gamma-lactams by simple zinc reduction (N-hydroxy amines) or by acid hydrolysis (sulfinamides). The diastereoselective preparation of various beta-methylenyl-gamma-lactams offers a route to tetramic acids, the key structural features of an important class of bioactive natural products.; China Scholarship Council [2010631073]; National Basic Research Program (973 Program) of China [2010CB833200]; NSF of China [20832005, 21072160]
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1021/ol300550x]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Xu, Chu-Pei,Huang, Pei-Qiang,Huang PQ,et al. SmI2-Mediated Coupling of Nitrones and tert-Butanesulfinyl Imines with Allenoates: Synthesis of beta-Methylenyl-gamma-lactams and Tetramic Acids[J],2012.
APA	Xu, Chu-Pei,Huang, Pei-Qiang,黄培强,&Py, Sandrine.(2012).SmI2-Mediated Coupling of Nitrones and tert-Butanesulfinyl Imines with Allenoates: Synthesis of beta-Methylenyl-gamma-lactams and Tetramic Acids..
MLA	Xu, Chu-Pei,et al."SmI2-Mediated Coupling of Nitrones and tert-Butanesulfinyl Imines with Allenoates: Synthesis of beta-Methylenyl-gamma-lactams and Tetramic Acids".(2012).

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