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	Differential methylation of CpG islands within the dermo1 gene promoter in several cancer cell lines
	Mao, Yubin ; Toh, Hween-Boon（ Natl Univ Singapore, Yong Loo Lin Sch Med） ; Ding, Zhijie（Xiamen Univ, Zhongshan Hosp） ; Sun, Lifang ; Hong, Liang（Huazhong Univ Sci & Technol） ; Chen, Chien-Shing（ Natl Univ Singapore, Yong Loo Lin Sch Med） ; Wu, Xueji ; Wu XJ(吴学记)
	2011-01
关键词	dermo1 methylation methylation-specific PCR real-time PCR cancer
英文摘要	Inactivation of tumor-related genes by promoter hypermethylation is a common epigenetic event in the development of variety of tumors. Dermal (also called twist2) is a novel cancer-related gene which belongs to the basic helix-loop-helix (bHLH) transcription factor family. Herein, we report that dermal expression was sporadically abrogated in human cancer cells by transcriptional silencing associated with CpG island promoter hypermethylation. Direct sequencing of bisulfite-modified DNA from a panel of seven human cancer cell lines (HL60, Molm14, MV4-11, RS4:11, MDM-BA231, H358, and H1299) revealed that CpG dinucleotides in the dermal promoter were methylated. RT-PCR results demonstrated that dermal CpG island hypermethylation was accompanied by a low basal dermal expression level. Our data implicate dermal as a tumor suppressor gene and a valuable molecular marker for human cancer.; Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry; National Natural Science Foundation of China[30872515]
语种	英语
出版者	SPANDIDOS PUBL LTD
内容类型	期刊论文
源URL	[http://dx.doi.org/doi:10.3892/or_00001048]
专题	化学化工－已发表论文
推荐引用方式 GB/T 7714	Mao, Yubin,Toh, Hween-Boon,Ding, Zhijie,et al. Differential methylation of CpG islands within the dermo1 gene promoter in several cancer cell lines[J],2011.
APA	Mao, Yubin.,Toh, Hween-Boon.,Ding, Zhijie.,Sun, Lifang.,Hong, Liang.,...&吴学记.(2011).Differential methylation of CpG islands within the dermo1 gene promoter in several cancer cell lines..
MLA	Mao, Yubin,et al."Differential methylation of CpG islands within the dermo1 gene promoter in several cancer cell lines".(2011).

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