Comparative embryotoxicity of phenanthrene and alkyl-phenanthrene to marine medaka (Oryzias melastigma)

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	Comparative embryotoxicity of phenanthrene and alkyl-phenanthrene to marine medaka (Oryzias melastigma)
	Mu, Jingli,,, ; Wang, Juyin ; Jin, Fei ; Wang, Xinhong ; Hong, Huashe ; Wang XH(王新红) ; Hong HS(洪华生)
刊名	http://dx.doi.org/10.1016/j.marpolbul.2014.01.040
	2014
关键词	Cardiovascular system Metabolites Oil spills Risk assessment Toxicity
英文摘要	Alkylated polycyclic aromatic hydrocarbons (alkyl-PAHs) are the predominant form of PAHs in oil, comprising 85-95% of total PAHs. However, little attention has been paid to these chemicals in ecological risk assessment of marine oil spill. A comparative study of the toxic effects of phenanthrene and retene (7-isopropyl-1-methylphenanthrene, an alkyl-phenanthrene) on the early life stage of marine medaka (Oryzias melastigma) was conducted. Results showed that retene was significantly more toxic than phenanthrene, and marine medaka could be more sensitive to retene than some freshwater fishes. Retene had a higher excretion rate than phenanthrene during the larvae stage. Both of compounds resulted in developmental malformation of marine medaka embryos, with phenanthrene affecting on peripheral vascular system and yolk sac, while retene affecting on cardiac tissues. The toxicity of phenanthrene might be mainly related to its anesthetic effects, and that of retene might be related to the CYP1A-mediated toxicity of its metabolites. ? 2014 Elsevier Ltd.
语种	英语
出版者	Elsevier Ltd
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/88255]
专题	海洋环境－已发表论文
推荐引用方式 GB/T 7714	Mu, Jingli,,,,Wang, Juyin,Jin, Fei,et al. Comparative embryotoxicity of phenanthrene and alkyl-phenanthrene to marine medaka (Oryzias melastigma)[J]. http://dx.doi.org/10.1016/j.marpolbul.2014.01.040,2014.
APA	Mu, Jingli,,,.,Wang, Juyin.,Jin, Fei.,Wang, Xinhong.,Hong, Huashe.,...&洪华生.(2014).Comparative embryotoxicity of phenanthrene and alkyl-phenanthrene to marine medaka (Oryzias melastigma).http://dx.doi.org/10.1016/j.marpolbul.2014.01.040.
MLA	Mu, Jingli,,,,et al."Comparative embryotoxicity of phenanthrene and alkyl-phenanthrene to marine medaka (Oryzias melastigma)".http://dx.doi.org/10.1016/j.marpolbul.2014.01.040 (2014).