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	Two-Compartment Toxicokinetic-Toxicodynamic Model to Predict Metal Toxicity in Daphnia magna
	Tan, Qiao-Guo ; Wang, Wen-Xiong ; Wang WX(王文雄)
	2012-09-04
关键词	BIOTIC LIGAND MODEL AQUATIC INVERTEBRATES BODY CONCENTRATIONS QUALITY GUIDELINES CADMIUM BIOACCUMULATION ACCUMULATION EXPOSURE MERCURY WATER
英文摘要	Relating the toxicity of metals to their internal concentration is difficult due to complicated detoxification processes within organisms. Only the metabolically available metals are potentially toxic to organisms, while metals in the detoxified form are toxicologically irrelevant. Accordingly, we developed a two-compartment toxicokinetic-toxicodynamic model for metals in a freshwater cladoceran, Daphnia magna. The toxicokinetics simulated the bioaccumulation processes, while the toxicodynamics quantitatively described the corresponding processes of toxicity development. Model parameters were estimated for D. magna and three metals, i.e., cadmium, zinc, and mercury, by fitting the literature data on metal bioaccumulation and toxicity. A range of crucial information for toxicity prediction can be readily derived from the model, including detoxification rate, no-effect concentration, threshold influx rate for toxicity, and maximum duration without toxicity. This process-based model is flexible and can help improve ecological risk assessments for metals.; China Postdoctoral Science Foundation [2011M500072]; program for Changjiang Scholars and Innovative Research Team in university (PCSIRT) [IRT0941]
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1021/es301987u]
专题	海洋环境－已发表论文
推荐引用方式 GB/T 7714	Tan, Qiao-Guo,Wang, Wen-Xiong,Wang WX. Two-Compartment Toxicokinetic-Toxicodynamic Model to Predict Metal Toxicity in Daphnia magna[J],2012.
APA	Tan, Qiao-Guo,Wang, Wen-Xiong,&王文雄.(2012).Two-Compartment Toxicokinetic-Toxicodynamic Model to Predict Metal Toxicity in Daphnia magna..
MLA	Tan, Qiao-Guo,et al."Two-Compartment Toxicokinetic-Toxicodynamic Model to Predict Metal Toxicity in Daphnia magna".(2012).

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