Development of multifunctional folate-poly(ethylene glycol)-chitosan-coated Fe3O4 nanoparticles for biomedical applications

CORC > 厦门大学 > 材料学院－已发表论文

	Development of multifunctional folate-poly(ethylene glycol)-chitosan-coated Fe3O4 nanoparticles for biomedical applications
	Zhou, Shuifan ; Li, Yang ; Cui, Fei ; Jia, Mengmeng ; Yang, Xiangrui ; Wang, Yange ; Xie, Liya ; Zhang, Qiqing ; Hou, Zhenqing ; Wang YG(王衍戈) ; Zhang QQ(张其清) ; Hou ZQ(侯振清)
刊名	http://dx.doi.org/10.1007/s13233-014-2008-y
	2014
关键词	Biocompatibility Cardiovascular system Chitosan Crosslinking Drug delivery Fourier transform infrared spectroscopy Hyperthermia therapy Magnetic susceptibility Medical applications Motion Picture Experts Group standards Nanoparticles -
英文摘要	The efficacy of magnetic nanoparticles (MNPs) for biomedical applications depends on the specic targeting capacity, blood circulation time and magnetic susceptibility. Functionalized chitosan-coated Fe3O4 nanoparticles (CS-coated Fe3O4 NPs) were synthesized by a non-solvent-aided coacervation procedure followed by a chemical crosslinking procedure. The surfaces of CS-coated Fe3O4 NPs were successfully functionalized with folate-poly(ethylene glycol)-COOH (FA-PEG) to obtain novel FA-PEG-CS-coated Fe3O4 NPs endowed with long blood circulation and specic targeting capacity. The as-synthesized NPs were characterized by dynamic light scattering, transmission electron microscope, X-ray diffraction, thermal gravimetric analysis, vibration sample magnetometer, Fourier transform infrared spectroscopy, and confocal laser scanning microscopy. As a result, the novel FA-PEG-CS-coated Fe3O4 NPs showed excellent biocompatibility, magnetic properties, good dispersibility, and proper hydrodynamic sizes in an aqueous medium. The specific targeting capacity of the as-synthesized NPs to cancer cells was also investigated. It was observed that the uptake of the FA-PEG-CS-coated Fe3O4 NPs by HeLa cells was significantly enhanced compared to the CS-coated Fe3O 4 NPs and mPEG-CS-coated Fe3O4 NPs. These results clearly indicate that our novel FA-PEG-CS-coated Fe3O 4 NPs with remarkable specific targeting capacity, long blood circulation, and superparamagnetism hold great promise for biomedical applications, including targeted drug delivery and hyperthermia therapy. [Figure not available: see fulltext.] ? 2014 The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht.
语种	英语
出版者	POLYMER SOC KOREA
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87483]
专题	材料学院－已发表论文
推荐引用方式 GB/T 7714	Zhou, Shuifan,Li, Yang,Cui, Fei,et al. Development of multifunctional folate-poly(ethylene glycol)-chitosan-coated Fe3O4 nanoparticles for biomedical applications[J]. http://dx.doi.org/10.1007/s13233-014-2008-y,2014.
APA	Zhou, Shuifan.,Li, Yang.,Cui, Fei.,Jia, Mengmeng.,Yang, Xiangrui.,...&侯振清.(2014).Development of multifunctional folate-poly(ethylene glycol)-chitosan-coated Fe3O4 nanoparticles for biomedical applications.http://dx.doi.org/10.1007/s13233-014-2008-y.
MLA	Zhou, Shuifan,et al."Development of multifunctional folate-poly(ethylene glycol)-chitosan-coated Fe3O4 nanoparticles for biomedical applications".http://dx.doi.org/10.1007/s13233-014-2008-y (2014).