Synthesis and characterization of NIR-responsive Au-rod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents

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	Synthesis and characterization of NIR-responsive Au-rod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents
	Shang, Ting ; Wang, Cai-ding ; Ren, Lei ; Tian, Xin-hua ; Li, Dong-hui ; Ke, Xue-bin ; Chen, Min ; Yang, An-qi ; Ren L(任磊) ; Tian XH(田新华) ; Li DH(李东辉) ; Chen M(陈敏)
刊名	http://dx.doi.org/10.1186/1556-276X-8-4
	2013
关键词	CONTROLLED DRUG-DELIVERY GOLD NANOPARTICLES TEMPERATURE DERIVATIVES NANORODS EFFICACY CANCER
英文摘要	National Basic Research Program of China [2010CB732402, 2013CB933703]; National Natural Science Foundation of China [30970733, 81171448]; A near-infrared (NIR)-responsive Au-rod@pNIPAAm-PEGMA nanogel was synthesized in two steps, growing a PEGMA monolayer on the surface of gold nanorods (AuNRs), followed by in situ polymerization and cross-linking of N-iso-propylacrylamide (NIPAAm) and poly-(ethylene glycol)-methacrylate (PEGMA). The AuNRs and Au-rod@pNIPAAm-PEGMA nanogel were characterized by UV-vis spectroscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy, respectively. The lower critical solution temperature of the Au-rod@pNIPAAm-PEGMA nanogel could be tuned by changing the molar ratio of NIPAAm/PEGMA. The NIR-mediated drug release behavior of the Au-rod@pNIPAAm-PEGMA nanogel was studied with zinc phthalocyanines (ZnPc4) as a drug model. It was also demonstrated that the loaded ZnPc4 could keep the capability of generating singlet oxygen, and the in vitro study showed a great photodynamic therapy (PDT) effect on Hela cells. It thus indicated the potential of this Au-rod@pNIPAAm-PEGMA nanogel for application as a drug carrier in PDT, which might make contributions to oncotherapy.
语种	英语
出版者	SPRINGER
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87208]
专题	材料学院－已发表论文
推荐引用方式 GB/T 7714	Shang, Ting,Wang, Cai-ding,Ren, Lei,et al. Synthesis and characterization of NIR-responsive Au-rod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents[J]. http://dx.doi.org/10.1186/1556-276X-8-4,2013.
APA	Shang, Ting.,Wang, Cai-ding.,Ren, Lei.,Tian, Xin-hua.,Li, Dong-hui.,...&陈敏.(2013).Synthesis and characterization of NIR-responsive Au-rod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents.http://dx.doi.org/10.1186/1556-276X-8-4.
MLA	Shang, Ting,et al."Synthesis and characterization of NIR-responsive Au-rod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents".http://dx.doi.org/10.1186/1556-276X-8-4 (2013).