| Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles | |
| Tian, Xin-Hua ; Lin, Xiao-Ning ; Wei, Feng ; Feng, Wei ; Huang, Zhi-Chun ; Wang, Peng ; Ren, Lei ; Diao, Yi ; Ren L(任磊) | |
| 2011 | |
| 关键词 | SOLID LIPID NANOPARTICLES DRUG-DELIVERY POLY(N-BUTYLCYANOACRYLATE) NANOPARTICLES CYANOACRYLATE) NANOPARTICLES BODY DISTRIBUTION IN-VITRO BARRIER TRANSPORT SYSTEMS RATS |
| 英文摘要 | Natural Science Foundation of Fujian Province of China; Xiamen Science and Technology Bureau of China; Background: Polybutylcyanoacrylate (PBCA) nanoparticles coated with polysorbate-80 have been extensively proposed for delivering drugs into the animal brain and have shown great potential for therapeutic applications. In this study, we made an attempt to deliver the chemotherapeutic drug, temozolomide, into the brain by using PBCA nanoparticles. The physicochemical characteristics, in vitro release, and brain targeting ability of the drug-loaded nanoparticles were investigated. Results: Our results show that a significantly higher concentration of temozolomide in the form of polysorbate-80-coated PBCA nanoparticles was observed in the brain (P < 0.05) in comparison with the free drug. Conclusion: This study indicates that polysorbate-80 coated PBCA nanoparticles could be a feasible carrier for temozolomide delivery to the brain. It is anticipated that the developed formulation may improve on targeted therapy for malignant brain tumors in the future. |
| 语种 | 英语 |
| 内容类型 | 期刊论文 |
| 源URL | [http://dspace.xmu.edu.cn/handle/2288/59010]  |
| 专题 | 材料学院－已发表论文 |
| 推荐引用方式 GB/T 7714 | Tian, Xin-Hua,Lin, Xiao-Ning,Wei, Feng,et al. Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles[J],2011. |
| APA | Tian, Xin-Hua.,Lin, Xiao-Ning.,Wei, Feng.,Feng, Wei.,Huang, Zhi-Chun.,...&任磊.(2011).Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles.. |
| MLA | Tian, Xin-Hua,et al."Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles".(2011). |
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