Fabrication of gelatin-siloxane fibrous mats via sol-gel and electrospinning procedure and its application for bone tissue engineering

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	Fabrication of gelatin-siloxane fibrous mats via sol-gel and electrospinning procedure and its application for bone tissue engineering
	Ren, Lei ; Wang, Jun ; Yang, Fang-Yu ; Wang, Lin ; Wang, Dong ; Wang, Tian-Xiao ; Tian, Miao-Miao ; Ren L(任磊)
刊名	http://dx.doi.org/10.1016/j.msec.2009.12.013
	2010-04-06
关键词	MESENCHYMAL STEM-CELLS STRUCTURAL EVOLUTION OSTEOBLASTIC CELLS IN-VITRO HYDROXYAPATITE HYBRID REGENERATION SCAFFOLDS NANOFIBERS FIBERS
英文摘要	National Natural Science Foundation of China [30670559]; National Basic Research Program of China (973 Program) [2007CB935603]; Program for New Century Excellent Talents in Fujian Province University; Our strategy is to design and fabricate biomimetic and bioactive scaffolds that resemble the native extracellular matrix as closely as possible so as to create conducive living milieu that will induce cell to function naturally. In the present study, gelatin/siloxane (GS) hybrids were prepared by a sol-gel processing, and electrospinning technique was used to fabricate GS fibrous mats to support the growth of bone marrow-derived mesenchymal stem cells (BMSCs) for tissue engineering of bone. The results indicate that the porous structure and fiber size of the GS fibrous mats can be fine tuned by varying the viscosity of GS precursor solution. Additionally, the Ca(2+)-containing GS fibrous mats biomimetically deposited apatite in a simulated body fluid (SBF), as well as stimulating its BMSCs proliferation and differentiation in vitro, thereby dignifying its in vitro bioactivity. (C) 2010 Elsevier B.V. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/59003]
专题	材料学院－已发表论文
推荐引用方式 GB/T 7714	Ren, Lei,Wang, Jun,Yang, Fang-Yu,et al. Fabrication of gelatin-siloxane fibrous mats via sol-gel and electrospinning procedure and its application for bone tissue engineering[J]. http://dx.doi.org/10.1016/j.msec.2009.12.013,2010.
APA	Ren, Lei.,Wang, Jun.,Yang, Fang-Yu.,Wang, Lin.,Wang, Dong.,...&任磊.(2010).Fabrication of gelatin-siloxane fibrous mats via sol-gel and electrospinning procedure and its application for bone tissue engineering.http://dx.doi.org/10.1016/j.msec.2009.12.013.
MLA	Ren, Lei,et al."Fabrication of gelatin-siloxane fibrous mats via sol-gel and electrospinning procedure and its application for bone tissue engineering".http://dx.doi.org/10.1016/j.msec.2009.12.013 (2010).