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	菠萝叶酚体外HepG2细胞跨膜转运及其对糖脂分布的影响
	庞雨浓 ; 柴玉爽 ; 姜敬非 ; 王欣佩 ; 余煊 ; 雷帆 ; 邢东明 ; 杜力军 ; PANG Yu-nong ; CHAI Yu-shuang ; JIANG Jing-fei ; WANG Xin-pei ; YU Xuan ; LEI Fan ; XING Dong-ming ; DU Li-jun
	2016-03-30 ; 2016-03-30
关键词	菠萝叶 跨膜转运 对香豆酸 脂类 葡萄糖 remote sensing evapotranspiration North China Plain cropland R285.5
其他题名	Transmembrane transport behavior of in vitro HepG2 cells of ananas and its effect on lipids and glucose distribution
中文摘要	菠萝叶主要含酚类成分,具有抗氧化和调血脂作用。其主要成分为对香豆酸。该文以对香豆酸为主要测试成分,观察了菠萝叶酚类成分中对香豆酸体外人源肝HepG2细胞跨膜转运的特点及其对糖脂负荷细胞实验中葡萄糖,总胆固醇和甘油三醇的转运代谢的影响。结果表明,菠萝叶酚具有较好的跨膜转运特点。给药后5 min,菠萝叶酚中的对香豆酸即细胞内达到较高的浓度,60 min达峰值。具有时间和剂量依赖性。在促进葡萄糖转运体(GLUT4)和低密度脂蛋白受体(LDLR)表达的同时,菠萝叶酚能够降低细胞内的糖脂含量。这种降低细胞内脂含量的作用与促进脂蛋白脂酶(LPL)、肝甘油三酯脂酶(HTGL)表达有关,降低细胞内葡萄糖含量的作用与促进肝糖原合成有关。; Pineapple( Ananas comosus) leaves contain mainly phenolic components with antioxidant and hypolipidemic effects. One of the principle components is p-coumaric acid. In this study,the transport behavior of p-coumaric acid,was observed after the administration of pineapple leaf phenols in vitro. Simultaneously,the effect of the phenols on glucose,total cholesterol and triglycerides transportation and metabolism in HepG2 cells was also observed. The results showed that the phenols had good transport characteristics. 5 min after the administration,p-coumaric acid of the phenols could be detected,and the content of p-coumaric acid reached the peak concentration after 60 min of the administration. p-coumaric acid of phenols have time-and dose-dependent manner.While promoting glucose transporter( GLUT4) and low density lipoprotein receptor( LDLR) expression,the phenols decreased intracellular lipid content. This reduction of intracellular lipid content was highly correlated with the promotion of lipoprotein lipase( LPL)and hepatic triglyceride lipase( HTGL) expression,while the reduction of intracellular glucose levels was correlated with glycogen synthesis in the cells.
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://ir.lib.tsinghua.edu.cn/ir/item.do?handle=123456789/148460]
专题	清华大学
推荐引用方式 GB/T 7714	庞雨浓,柴玉爽,姜敬非,等. 菠萝叶酚体外HepG2细胞跨膜转运及其对糖脂分布的影响[J],2016, 2016.
APA	庞雨浓.,柴玉爽.,姜敬非.,王欣佩.,余煊.,...&DU Li-jun.(2016).菠萝叶酚体外HepG2细胞跨膜转运及其对糖脂分布的影响..
MLA	庞雨浓,et al."菠萝叶酚体外HepG2细胞跨膜转运及其对糖脂分布的影响".(2016).

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