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	Molecularly imprinted polymer for pre-concentration of esculetin from tobacco followed by the UPLC analysis
	RAZWAN SARDAR M. ; JIN Yan ; KONG Guang Hui ; LI Hai Fang ; LIN Jin-Ming ; RAZWAN SARDAR M. ; JIN Yan ; KONG Guang Hui ; LI Hai Fang ; LIN Jin-Ming
	2016-03-30 ; 2016-03-30
关键词	molecularly imprinted polymer esculetin tobacco UPLC O631.3
其他题名	Molecularly imprinted polymer for pre-concentration of esculetin from tobacco followed by the UPLC analysis
中文摘要	Molecularly imprinted polymers(MIPs)for solid-phase extraction and pre-concentration of esculetin have been successfully prepared by the bulk polymerization method using esculetin as a template molecule.Polymers of varying composition were prepared using different monomers(4-vinylpyridine,methacrylic acid,and acrylamide),ethylene glycol dimethacrylate as the cross-linker,2,2-azobis(2-methylpropinitrile)as the initiator,and different porogen solvents(ethanol,acetone/methanol,and acetonitrile).The best polymer was obtained when 4-vinylpyridine was used as the monomer and acetone/methanol(3:2)as the porogen solvent,whereas the template:-monomer:-cross-linker ratio was 1:4:20.The imprinting factor of the selected MIPs for esculetin was 3.77.The polymers were evaluated according to their selective recognition properties for esculetin and structurally-related compounds(esculin,scopoletin,coumarin,and 7-methoxycoumarin).Chemical and morphological characterizations of the polymers were investigated by FTIR and scanning electron microscope,which confirmed a high degree of polymerization.Surface area,pore volume,and pore size of the polymer were investigated by Brunauer-Emmett-Teller analysis.MIPs were also successfully used as solid-phase adsorbent materials for the extraction of esculetin from tobacco leaves.Esculetin contents in dried tobacco leaves were found to be(9.27±0.17)μg g-1.; Molecularly imprinted polymers(MIPs) for solid-phase extraction and pre-concentration of esculetin have been successfully prepared by the bulk polymerization method using esculetin as a template molecule. Polymers of varying composition were prepared using different monomers(4-vinylpyridine, methacrylic acid, and acrylamide), ethylene glycol dimethacrylate as the cross-linker, 2,2-azobis(2-methylpropinitrile) as the initiator, and different porogen solvents(ethanol, acetone/methanol, and acetonitrile). The best polymer was obtained when 4-vinylpyridine was used as the monomer and acetone/methanol(3:2) as the porogen solvent, whereas the template:-monomer:-cross-linker ratio was 1:4:20. The imprinting factor of the selected MIPs for esculetin was 3.77. The polymers were evaluated according to their selective recognition properties for esculetin and structurally-related compounds(esculin, scopoletin, coumarin, and 7-methoxycoumarin). Chemical and morphological characterizations of the polymers were investigated by FTIR and scanning electron microscope, which confirmed a high degree of polymerization. Surface area, pore volume, and pore size of the polymer were investigated by Brunauer-Emmett-Teller analysis. MIPs were also successfully used as solid-phase adsorbent materials for the extraction of esculetin from tobacco leaves. Esculetin contents in dried tobacco leaves were found to be(9.27±0.17) μg g-1.
语种	英语 ; 英语
内容类型	期刊论文
源URL	[http://ir.lib.tsinghua.edu.cn/ir/item.do?handle=123456789/145947]
专题	清华大学
推荐引用方式 GB/T 7714	RAZWAN SARDAR M.,JIN Yan,KONG Guang Hui,et al. Molecularly imprinted polymer for pre-concentration of esculetin from tobacco followed by the UPLC analysis[J],2016, 2016.
APA	RAZWAN SARDAR M..,JIN Yan.,KONG Guang Hui.,LI Hai Fang.,LIN Jin-Ming.,...&LIN Jin-Ming.(2016).Molecularly imprinted polymer for pre-concentration of esculetin from tobacco followed by the UPLC analysis..
MLA	RAZWAN SARDAR M.,et al."Molecularly imprinted polymer for pre-concentration of esculetin from tobacco followed by the UPLC analysis".(2016).

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