| 肿瘤磁感应治疗计划系统适形热疗方法 | |
| 卓子寒 ; 翟伟明 ; 蔡东阳 ; 王婕 ; 张晓冬 ; 唐劲天 ; ZHUO Zihan ; ZHAI Weiming ; CAI Dongyang ; WANG Jie ; ZHANG Xiaodong ; TANG Jintian | |
| 2016-03-30 ; 2016-03-30 | |
| 关键词 | 肿瘤热疗 磁感应治疗 术前计划 建模仿真 tumor hyperthermia magnetic induction therapy preoperative planning modeling and simulation R730.59 |
| 其他题名 | Conformal treatment method for tumor magnetic induction hyperthermia treatment planning system |
| 中文摘要 | 磁感应热疗在临床实施时,需要达到适形杀灭肿瘤和保护正常组织的治疗目标,因此要求在术前治疗计划系统中对靶区的温度分布情况进行数值模拟,以指导医生制定合适的治疗计划,确保治疗的安全性和有效性。该文基于VTK/ITK等医学影像开源算法工具包,采用医学CT影像3维重建数据场信息,对磁感应热疗过程中治疗区域内的肿瘤及其周围组织进行可视化和适形分割,以确立治疗靶区和植入热籽;基于电磁学和生物传热学的理论方法,以及肿瘤内的适形热籽排布方案,对治疗时热籽磁热效应产生的能量场分布和热量扩散形成的温度场分布进行理论建模和仿真;并将适形热疗方法实际应用于肿瘤磁感应热疗计划系统中。结果表明:磁感应治疗计划系统的适形热疗方法可以辅助医生直观地分割肿瘤和组织器官,进而准确计算靶区的温度场分布,制定合理的适形热疗计划。; Clinical implementation of magnetic induction hyperthermia(MIH)seeks to conformally killing tumor cells while protecting the normal tissue.Thus,the temperature distribution in the treatment area needs to be accurately simulated by the preoperative treatment planning systems(TPS)to help the surgeon make an appropriate clinical plan to ensure the safety and efficacy of the MIH therapy.Medical image open source toolkits,such as VTK and ITK,can give accurate 3-D reconstruction,visualization and segmentation of tumors and their surrounding tissue from 2-D CT images.Then,ferromagnetic thermoseeds are implanted into the tumor region.Electromagnetism and bio-heat transfer theories are used to predict the energy fields generated by the thermoseeds and the temperature distributions due to the heat diffusion in the MIH process.This conformal-hyperthermia method can be applied in magnetic induction hyperthermia treatment planning systems(MHTPS).The results show that the conformal-hyperthermia method in MHTPS can help surgeons intuitively segment tumors,accurately predict the temperature distributions in the treatment area,and make reasonable preoperative plans. |
| 语种 | 中文 ; 中文 |
| 内容类型 | 期刊论文 |
| 源URL | [http://ir.lib.tsinghua.edu.cn/ir/item.do?handle=123456789/143191]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | 卓子寒,翟伟明,蔡东阳,等. 肿瘤磁感应治疗计划系统适形热疗方法[J],2016, 2016. |
| APA | 卓子寒.,翟伟明.,蔡东阳.,王婕.,张晓冬.,...&TANG Jintian.(2016).肿瘤磁感应治疗计划系统适形热疗方法.. |
| MLA | 卓子寒,et al."肿瘤磁感应治疗计划系统适形热疗方法".(2016). |
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