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	Effects of Acrylamide on the Activity and Structure of Human Brain Creatine Kinase
	Sheng, Qing ; Zou, He-Chang ; Lue, Zhi-Rong ; Zou, Fei ; Park, Yong-Doo ; Yan, Yong-Bin ; Yao, Shan-Jing
	2010-10-12 ; 2010-10-12 ; OCT
关键词	acrylamide human brain creatine kinase inactivation docking simulation DISEASE BRAIN STABILITY MOLECULE SAFETY FOOD INACTIVATION ISOENZYMES PROTEINS TISSUES Chemistry, Multidisciplinary
中文摘要	Acrylamide is widely used worldwide in industry and it can also be produced by the cooking and processing of foods. It is harmful to human beings, and human brain CK (HBCK) has been proposed to be one of the important targets of acrylamide. In this research, we studied the effects of acrylamide on HBCK activity, structure and the potential binding sites. Compared to CKs from rabbit, HBCK was fully inactivated at several-fold lower concentrations of acrylamide, and exhibited distinct properties upon acrylamide-induced inactivation and structural changes. The binding sites of acrylamide were located at the cleft between the N- and C-terminal domains of CK, and Glu232 was one of the key binding residues. The effects of acrylamide on CK were proposed to be isoenzyme- and species-specific, and the underlying molecular mechanisms were discussed.
语种	英语 ; 英语
出版者	MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI ; BASEL ; KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81865]
专题	清华大学
推荐引用方式 GB/T 7714	Sheng, Qing,Zou, He-Chang,Lue, Zhi-Rong,et al. Effects of Acrylamide on the Activity and Structure of Human Brain Creatine Kinase[J],2010, 2010, OCT.
APA	Sheng, Qing.,Zou, He-Chang.,Lue, Zhi-Rong.,Zou, Fei.,Park, Yong-Doo.,...&Yao, Shan-Jing.(2010).Effects of Acrylamide on the Activity and Structure of Human Brain Creatine Kinase..
MLA	Sheng, Qing,et al."Effects of Acrylamide on the Activity and Structure of Human Brain Creatine Kinase".(2010).

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